Effect of impairment of renal function on the accumulation and disposition of isoxicam

ISSN:
1432-1041
Keywords:
isoxicam ; pharmacokinetics ; renal failure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Medicine
Notes:
Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295564338593792
autor Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
autorsonst Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
book_url http://dx.doi.org/10.1007/BF00544071
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM202425436
issn 1432-1041
journal_name European journal of clinical pharmacology
materialart 1
notes Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
package_name Springer
publikationsjahr_anzeige 1985
publikationsjahr_facette 1985
publikationsjahr_intervall 8014:1985-1989
publikationsjahr_sort 1985
publisher Springer
reference 28 (1985), S. 585-588
schlagwort isoxicam
pharmacokinetics
renal failure
search_space articles
shingle_author_1 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
shingle_author_2 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
shingle_author_3 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
shingle_author_4 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
shingle_catch_all_1 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
Effect of impairment of renal function on the accumulation and disposition of isoxicam
isoxicam
pharmacokinetics
renal failure
isoxicam
pharmacokinetics
renal failure
Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
1432-1041
14321041
Springer
shingle_catch_all_2 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
Effect of impairment of renal function on the accumulation and disposition of isoxicam
isoxicam
pharmacokinetics
renal failure
isoxicam
pharmacokinetics
renal failure
Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
1432-1041
14321041
Springer
shingle_catch_all_3 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
Effect of impairment of renal function on the accumulation and disposition of isoxicam
isoxicam
pharmacokinetics
renal failure
isoxicam
pharmacokinetics
renal failure
Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
1432-1041
14321041
Springer
shingle_catch_all_4 Bury, R. W.
Whitworth, J. A.
Saines, D.
Kincaid-Smith, P.
Moulds, R. F. W.
Effect of impairment of renal function on the accumulation and disposition of isoxicam
isoxicam
pharmacokinetics
renal failure
isoxicam
pharmacokinetics
renal failure
Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
1432-1041
14321041
Springer
shingle_title_1 Effect of impairment of renal function on the accumulation and disposition of isoxicam
shingle_title_2 Effect of impairment of renal function on the accumulation and disposition of isoxicam
shingle_title_3 Effect of impairment of renal function on the accumulation and disposition of isoxicam
shingle_title_4 Effect of impairment of renal function on the accumulation and disposition of isoxicam
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timestamp 2024-05-06T09:38:12.780Z
titel Effect of impairment of renal function on the accumulation and disposition of isoxicam
titel_suche Effect of impairment of renal function on the accumulation and disposition of isoxicam
topic V
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