Effect of impairment of renal function on the accumulation and disposition of isoxicam
Bury, R. W. ; Whitworth, J. A. ; Saines, D. ; Kincaid-Smith, P. ; Moulds, R. F. W.
Springer
Published 1985
Springer
Published 1985
| ISSN: |
1432-1041
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|---|---|
| Keywords: |
isoxicam ; pharmacokinetics ; renal failure
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Chemistry and Pharmacology
Medicine
|
| Notes: |
Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295564338593792 |
|---|---|
| autor | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. |
| autorsonst | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. |
| book_url | http://dx.doi.org/10.1007/BF00544071 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM202425436 |
| issn | 1432-1041 |
| journal_name | European journal of clinical pharmacology |
| materialart | 1 |
| notes | Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects. |
| package_name | Springer |
| publikationsjahr_anzeige | 1985 |
| publikationsjahr_facette | 1985 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1985 |
| publisher | Springer |
| reference | 28 (1985), S. 585-588 |
| schlagwort | isoxicam pharmacokinetics renal failure |
| search_space | articles |
| shingle_author_1 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. |
| shingle_author_2 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. |
| shingle_author_3 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. |
| shingle_author_4 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. |
| shingle_catch_all_1 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. Effect of impairment of renal function on the accumulation and disposition of isoxicam isoxicam pharmacokinetics renal failure isoxicam pharmacokinetics renal failure Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects. 1432-1041 14321041 Springer |
| shingle_catch_all_2 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. Effect of impairment of renal function on the accumulation and disposition of isoxicam isoxicam pharmacokinetics renal failure isoxicam pharmacokinetics renal failure Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects. 1432-1041 14321041 Springer |
| shingle_catch_all_3 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. Effect of impairment of renal function on the accumulation and disposition of isoxicam isoxicam pharmacokinetics renal failure isoxicam pharmacokinetics renal failure Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects. 1432-1041 14321041 Springer |
| shingle_catch_all_4 | Bury, R. W. Whitworth, J. A. Saines, D. Kincaid-Smith, P. Moulds, R. F. W. Effect of impairment of renal function on the accumulation and disposition of isoxicam isoxicam pharmacokinetics renal failure isoxicam pharmacokinetics renal failure Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects. 1432-1041 14321041 Springer |
| shingle_title_1 | Effect of impairment of renal function on the accumulation and disposition of isoxicam |
| shingle_title_2 | Effect of impairment of renal function on the accumulation and disposition of isoxicam |
| shingle_title_3 | Effect of impairment of renal function on the accumulation and disposition of isoxicam |
| shingle_title_4 | Effect of impairment of renal function on the accumulation and disposition of isoxicam |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:38:12.780Z |
| titel | Effect of impairment of renal function on the accumulation and disposition of isoxicam |
| titel_suche | Effect of impairment of renal function on the accumulation and disposition of isoxicam |
| topic | V WW-YZ |
| uid | nat_lic_papers_NLM202425436 |