Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin

ISSN:
1432-1106
Keywords:
Plasticity ; Enkephalin ; Vasoactive intestinal polypeptide ; Somatostatin ; Neuropeptide tyrosine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2–3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP-or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons, but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be downregulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00229360
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autor Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
autorsonst Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
book_url http://dx.doi.org/10.1007/BF00229360
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM202306437
issn 1432-1106
journal_name Experimental brain research
materialart 1
notes Abstract The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2–3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP-or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons, but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be downregulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
package_name Springer
publikationsjahr_anzeige 1993
publikationsjahr_facette 1993
publikationsjahr_intervall 8009:1990-1994
publikationsjahr_sort 1993
publisher Springer
reference 93 (1993), S. 450-461
schlagwort Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
search_space articles
shingle_author_1 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
shingle_author_2 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
shingle_author_3 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
shingle_author_4 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
shingle_catch_all_1 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Abstract The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2–3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP-or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons, but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be downregulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
1432-1106
14321106
Springer
shingle_catch_all_2 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Abstract The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2–3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP-or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons, but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be downregulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
1432-1106
14321106
Springer
shingle_catch_all_3 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Abstract The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2–3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP-or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons, but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be downregulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
1432-1106
14321106
Springer
shingle_catch_all_4 Zhang, X.
Verge, V. M. K.
Wiesenfeld-Hallin, Z.
Piehl, F.
Hökfelt, T.
Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Plasticity
Enkephalin
Vasoactive intestinal polypeptide
Somatostatin
Neuropeptide tyrosine
Abstract The extent to which the plasticity in peptide expression observed in developing spinal motoneurons occurs following proximal peripheral axotomy in the adult rat was examined using in situ hybridization and immunohistochemical techniques to visualize the changes. Transient upregulation of galanin, vasoactive intestinal polypeptide (VIP) and substance P messenger ribonucleic acids (mRNAs) was observed within subpopulations of motoneurons ipsilateral to lesion for periods lasting 2–3 weeks after injury. In contrast, the axotomy-induced heterogenous increases in somatostatin and neuropeptide tyrosine mRNA expression in ipsilateral motoneurons remained elevated, or, in the case of somatostatin, continued to increase for the time period studied (1 month). Immunohistochemical analysis agreed with the in situ hybridization results, showing some motoneurons within the injured ventral horn to contain galanin-, VIP-or somatostatin-like immunoreactivity. In some instances, galanin-immunoreactive motoneurons colocalized with calcitonin gene-related peptide immunoreactivity. Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons, but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion. This may represent evidence for peptide synthesis in gamma-motoneurons. The only peptide mRNA studied to be downregulated in response to axotomy was enkephalin. The results show that peptide expression in injured motoneurons is dramatically altered, the significance of which remains to be determined.
1432-1106
14321106
Springer
shingle_title_1 Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
shingle_title_2 Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
shingle_title_3 Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
shingle_title_4 Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
sigel_instance_filter dkfz
geomar
wilbert
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:38:45.087Z
titel Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
titel_suche Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin
topic WW-YZ
uid nat_lic_papers_NLM202306437