The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study
| ISSN: |
1432-1106
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|---|---|
| Keywords: |
5-Hydroxytryptophan ; Parachlorophenylalanine ; Benserazide ; Sleep ; Rat
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-aciddecarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295597656047616 |
|---|---|
| autor | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. |
| autorsonst | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. |
| book_url | http://dx.doi.org/10.1007/BF00231046 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM20230096X |
| issn | 1432-1106 |
| journal_name | Experimental brain research |
| materialart | 1 |
| notes | Summary In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-aciddecarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP. |
| package_name | Springer |
| publikationsjahr_anzeige | 1991 |
| publikationsjahr_facette | 1991 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1991 |
| publisher | Springer |
| reference | 86 (1991), S. 117-124 |
| schlagwort | 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat |
| search_space | articles |
| shingle_author_1 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. |
| shingle_author_2 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. |
| shingle_author_3 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. |
| shingle_author_4 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. |
| shingle_catch_all_1 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat Summary In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-aciddecarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP. 1432-1106 14321106 Springer |
| shingle_catch_all_2 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat Summary In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-aciddecarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP. 1432-1106 14321106 Springer |
| shingle_catch_all_3 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat Summary In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-aciddecarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP. 1432-1106 14321106 Springer |
| shingle_catch_all_4 | Touret, M. Sarda, N. Gharib, A. Geffard, M. Jouvet, M. The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat 5-Hydroxytryptophan Parachlorophenylalanine Benserazide Sleep Rat Summary In the rat, the insomnia which follows the administration of parachlorophenylalanine (p-CPA), a serotonin synthesis inhibitor, is transiently reversed either by intra-cisternal injection of L-5-HTP or by an associated injection of 5-HTP and an L-aromatic-aciddecarboxylase inhibitor (benserazide). Histochemical, immunohistochemical and chemical investigations showed that 5-HTP administration does not lead to a detectable increase in cerebral 5-HT. These findings suggest that the restoration of sleep after p-CPA treatment could be mediated by the central action of 5-HTP. 1432-1106 14321106 Springer |
| shingle_title_1 | The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study |
| shingle_title_2 | The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study |
| shingle_title_3 | The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study |
| shingle_title_4 | The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:38:44.242Z |
| titel | The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study |
| titel_suche | The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM20230096X |