Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures

ISSN:
1432-1106
Keywords:
Key words Cocaine ; Development ; MAP2 ; D1dopamine receptor ; Parvalbumin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract  Previous studies have reported that cocaine exposure in utero results in structural and functional alterations in the development of the anterior cingulate cortex (ACC). In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied. The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded. No GTCSs were elicited in pregnant rabbits by doses of 2 or 3 mg/kg of cocaine, but GTCSs were sometimes elicited by the highest dose (4 mg/kg per injection). We analyzed the offspring of cocaine-exposed and control animals using three assays of ACC development: (i) the structure of apical dendrites of pyramidal neurons, (ii) the distribution of a calcium binding protein (parvalbumin) in the dendrites of GABAergic neurons, and (iii) coupling of D1-like receptors and their G proteins. In all progeny of rabbits exposed to 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of apical dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling. In assays of apical dendrites, the effects on offspring of rabbits given 2 mg/kg cocaine were as pronounced as in offspring of rabbits given 3 or 4 mg/kg, but the effects on parvalbumin immunoreactivity and D1/G protein coupling were reduced at this low dose. Thus, previous findings of ACC developmental abnormalities in offspring of rabbits given a dose of 4 mg/kg were replicated, the effects were shown to be dose-related and to be independent of maternal seizures. A mechanism by which dysfunction of the D1receptor system could mediate cocaine-associated changes in all three parameters of ACC structure and function is discussed.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295591026950144
autor Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
autorsonst Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
book_url http://dx.doi.org/10.1007/PL00005652
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM202246035
issn 1432-1106
journal_name Experimental brain research
materialart 1
notes Abstract  Previous studies have reported that cocaine exposure in utero results in structural and functional alterations in the development of the anterior cingulate cortex (ACC). In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied. The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded. No GTCSs were elicited in pregnant rabbits by doses of 2 or 3 mg/kg of cocaine, but GTCSs were sometimes elicited by the highest dose (4 mg/kg per injection). We analyzed the offspring of cocaine-exposed and control animals using three assays of ACC development: (i) the structure of apical dendrites of pyramidal neurons, (ii) the distribution of a calcium binding protein (parvalbumin) in the dendrites of GABAergic neurons, and (iii) coupling of D1-like receptors and their G proteins. In all progeny of rabbits exposed to 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of apical dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling. In assays of apical dendrites, the effects on offspring of rabbits given 2 mg/kg cocaine were as pronounced as in offspring of rabbits given 3 or 4 mg/kg, but the effects on parvalbumin immunoreactivity and D1/G protein coupling were reduced at this low dose. Thus, previous findings of ACC developmental abnormalities in offspring of rabbits given a dose of 4 mg/kg were replicated, the effects were shown to be dose-related and to be independent of maternal seizures. A mechanism by which dysfunction of the D1receptor system could mediate cocaine-associated changes in all three parameters of ACC structure and function is discussed.
package_name Springer
publikationsjahr_anzeige 1997
publikationsjahr_facette 1997
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1997
publisher Springer
reference 114 (1997), S. 433-441
schlagwort Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
search_space articles
shingle_author_1 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
shingle_author_2 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
shingle_author_3 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
shingle_author_4 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
shingle_catch_all_1 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Abstract  Previous studies have reported that cocaine exposure in utero results in structural and functional alterations in the development of the anterior cingulate cortex (ACC). In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied. The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded. No GTCSs were elicited in pregnant rabbits by doses of 2 or 3 mg/kg of cocaine, but GTCSs were sometimes elicited by the highest dose (4 mg/kg per injection). We analyzed the offspring of cocaine-exposed and control animals using three assays of ACC development: (i) the structure of apical dendrites of pyramidal neurons, (ii) the distribution of a calcium binding protein (parvalbumin) in the dendrites of GABAergic neurons, and (iii) coupling of D1-like receptors and their G proteins. In all progeny of rabbits exposed to 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of apical dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling. In assays of apical dendrites, the effects on offspring of rabbits given 2 mg/kg cocaine were as pronounced as in offspring of rabbits given 3 or 4 mg/kg, but the effects on parvalbumin immunoreactivity and D1/G protein coupling were reduced at this low dose. Thus, previous findings of ACC developmental abnormalities in offspring of rabbits given a dose of 4 mg/kg were replicated, the effects were shown to be dose-related and to be independent of maternal seizures. A mechanism by which dysfunction of the D1receptor system could mediate cocaine-associated changes in all three parameters of ACC structure and function is discussed.
1432-1106
14321106
Springer
shingle_catch_all_2 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Abstract  Previous studies have reported that cocaine exposure in utero results in structural and functional alterations in the development of the anterior cingulate cortex (ACC). In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied. The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded. No GTCSs were elicited in pregnant rabbits by doses of 2 or 3 mg/kg of cocaine, but GTCSs were sometimes elicited by the highest dose (4 mg/kg per injection). We analyzed the offspring of cocaine-exposed and control animals using three assays of ACC development: (i) the structure of apical dendrites of pyramidal neurons, (ii) the distribution of a calcium binding protein (parvalbumin) in the dendrites of GABAergic neurons, and (iii) coupling of D1-like receptors and their G proteins. In all progeny of rabbits exposed to 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of apical dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling. In assays of apical dendrites, the effects on offspring of rabbits given 2 mg/kg cocaine were as pronounced as in offspring of rabbits given 3 or 4 mg/kg, but the effects on parvalbumin immunoreactivity and D1/G protein coupling were reduced at this low dose. Thus, previous findings of ACC developmental abnormalities in offspring of rabbits given a dose of 4 mg/kg were replicated, the effects were shown to be dose-related and to be independent of maternal seizures. A mechanism by which dysfunction of the D1receptor system could mediate cocaine-associated changes in all three parameters of ACC structure and function is discussed.
1432-1106
14321106
Springer
shingle_catch_all_3 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Abstract  Previous studies have reported that cocaine exposure in utero results in structural and functional alterations in the development of the anterior cingulate cortex (ACC). In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied. The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded. No GTCSs were elicited in pregnant rabbits by doses of 2 or 3 mg/kg of cocaine, but GTCSs were sometimes elicited by the highest dose (4 mg/kg per injection). We analyzed the offspring of cocaine-exposed and control animals using three assays of ACC development: (i) the structure of apical dendrites of pyramidal neurons, (ii) the distribution of a calcium binding protein (parvalbumin) in the dendrites of GABAergic neurons, and (iii) coupling of D1-like receptors and their G proteins. In all progeny of rabbits exposed to 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of apical dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling. In assays of apical dendrites, the effects on offspring of rabbits given 2 mg/kg cocaine were as pronounced as in offspring of rabbits given 3 or 4 mg/kg, but the effects on parvalbumin immunoreactivity and D1/G protein coupling were reduced at this low dose. Thus, previous findings of ACC developmental abnormalities in offspring of rabbits given a dose of 4 mg/kg were replicated, the effects were shown to be dose-related and to be independent of maternal seizures. A mechanism by which dysfunction of the D1receptor system could mediate cocaine-associated changes in all three parameters of ACC structure and function is discussed.
1432-1106
14321106
Springer
shingle_catch_all_4 Murphy, E. H.
Fischer, Itzhak
Friedman, Eitan
Grayson, Dennis
Jones, Liesl
Levitt, P.
O’Brien-Jenkins, A.
Wang, Hoau-Yan
Wang, Xiao-Hui
Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Key words Cocaine
Development
MAP2
D1dopamine receptor
Parvalbumin
Abstract  Previous studies have reported that cocaine exposure in utero results in structural and functional alterations in the development of the anterior cingulate cortex (ACC). In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied. The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded. No GTCSs were elicited in pregnant rabbits by doses of 2 or 3 mg/kg of cocaine, but GTCSs were sometimes elicited by the highest dose (4 mg/kg per injection). We analyzed the offspring of cocaine-exposed and control animals using three assays of ACC development: (i) the structure of apical dendrites of pyramidal neurons, (ii) the distribution of a calcium binding protein (parvalbumin) in the dendrites of GABAergic neurons, and (iii) coupling of D1-like receptors and their G proteins. In all progeny of rabbits exposed to 3 or 4 mg/kg of cocaine during pregnancy, there was a significant change in the structure of apical dendrites, a significant increase in the number of dendrites of GABAergic neurons which were parvalbumin immunoreactive, and a significant reduction in D1/G protein coupling. In assays of apical dendrites, the effects on offspring of rabbits given 2 mg/kg cocaine were as pronounced as in offspring of rabbits given 3 or 4 mg/kg, but the effects on parvalbumin immunoreactivity and D1/G protein coupling were reduced at this low dose. Thus, previous findings of ACC developmental abnormalities in offspring of rabbits given a dose of 4 mg/kg were replicated, the effects were shown to be dose-related and to be independent of maternal seizures. A mechanism by which dysfunction of the D1receptor system could mediate cocaine-associated changes in all three parameters of ACC structure and function is discussed.
1432-1106
14321106
Springer
shingle_title_1 Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
shingle_title_2 Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
shingle_title_3 Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
shingle_title_4 Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:38:37.613Z
titel Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
titel_suche Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures
topic WW-YZ
uid nat_lic_papers_NLM202246035