Nucleotide-sensitive ion channels in human insulin producing tumour cells
Sturgess, Nicholas C. ; Carrington, Christine A. ; Hales, C. Nicholas ; Ashford, Michael L. J.
Springer
Published 1987
Springer
Published 1987
| ISSN: |
1432-2013
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|---|---|
| Keywords: |
Nucleotides ; Insulin-secretion ; Sulphonylureas ; Human cells ; Cation channels
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Cells from a human insulin producing tumour have been studied and single channel currents recorded. We have observed three main cation-selective channels in excised patch experiments. An ATP-sensitive potassium channel is present the activity of which can be inhibited by the oral hypoglycaemic drug, tolbutamide. A calcium-activated nonselective cation channel, which is inhibited by AMP could also be seen. In addition a large conductance potassium selective channel, possibly the “maxi” calcium-activated potassium channel is present in these cells.
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| Type of Medium: |
Electronic Resource
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| URL: |