Thermoregulation during fever: Change of set-point or change of gain
| ISSN: |
1432-2013
|
|---|---|
| Keywords: |
Fever ; Thermoregulation ; Set-Point ; Physiological Control ; Fieber ; “Set”-Punkt ; Physiologische Kontrolle
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Summary Thermoregulation during fever is generally described in terms of a change in the level of the reference signal in the control system. This paper presents an alternative postulate, namely that during fever the thermoregulatory control centre undergoes a pyrogen-induced change in sensitivity, or gain. This postulate is supported strongly by the behaviour of thermoregulatory neurones. Febrile and afebrile thermoregulation can be described by means of a model with no reference signal at all, but with opposing warm and cold stimuli to the control centre.
|
| Type of Medium: |
Electronic Resource
|
| URL: |