Dose-response curves of homovanillic acid in pre-frontal cortex and caudate following antipsychotic drugs: relation to clinical potencies
| ISSN: |
1432-2072
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| Keywords: |
Dose-response curve ; Homovanillic acid ; Prefrontal cortex ; Caudate ; Antipsychotic drugs
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Dose-response curves for the elevation of homovanillic acid (HVA) levels, determined by high performance liquid chromatography using electrochemical detection, in the pre-frontal cortex and caudate of rats after acute treatment with 12 antipsychotic drugs are presented. The order of potency in both brain regions was: haloperidol ≥ fluphenazine 〉 loxapine 〉 trifluoperazine 〉 thiothixene 〉 molindone 〉 clopenthixol 〉 chlorpromazine 〉 metoclopramide 〉 thioridazine 〉 clozapine 〉 sulpiride. This ranking is roughly correlated with that based on clinical potencies. The relative elevation of the content of HVA was weaker in the pre-frontal cortex than in the caudate for all drugs tested, except clozapine at a high dose.
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| Type of Medium: |
Electronic Resource
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| URL: |