Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients
Post, Robert M. ; Rubinow, David R. ; Uhde, Thomas W. ; Ballenger, James C. ; Lake, C. Raymond ; Linnoila, Markku ; Jimerson, David C. ; Reus, Victor
Springer
Published 1985
Springer
Published 1985
| ISSN: |
1432-2072
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|---|---|
| Keywords: |
Norepinephrine ; 3-Methoxy-4-hydroxyphenylglycol ; Manic-depressive illness ; Carbamazepine ; Cerebrospinal fluid
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295939660644352 |
|---|---|
| autor | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor |
| autorsonst | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor |
| book_url | http://dx.doi.org/10.1007/BF00431779 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM200790773 |
| issn | 1432-2072 |
| journal_name | Psychopharmacology |
| materialart | 1 |
| notes | Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man. |
| package_name | Springer |
| publikationsjahr_anzeige | 1985 |
| publikationsjahr_facette | 1985 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1985 |
| publisher | Springer |
| reference | 87 (1985), S. 59-63 |
| schlagwort | Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid |
| search_space | articles |
| shingle_author_1 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor |
| shingle_author_2 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor |
| shingle_author_3 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor |
| shingle_author_4 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor |
| shingle_catch_all_1 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man. 1432-2072 14322072 Springer |
| shingle_catch_all_2 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man. 1432-2072 14322072 Springer |
| shingle_catch_all_3 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man. 1432-2072 14322072 Springer |
| shingle_catch_all_4 | Post, Robert M. Rubinow, David R. Uhde, Thomas W. Ballenger, James C. Lake, C. Raymond Linnoila, Markku Jimerson, David C. Reus, Victor Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Norepinephrine 3-Methoxy-4-hydroxyphenylglycol Manic-depressive illness Carbamazepine Cerebrospinal fluid Abstract Noradrenergic mechanisms have been postulated to account for the anticonvulsant and psychotropic effects of carbamazepine. In order to assess this possibility in man, cerebrospinal fluid (CSF) was obtained from affectively ill patients before and during treatment with carbamazepine (average duration 29 days) at doses averaging 860 mg/day, achieving blood levels of 8.86 μg/ml. Neither plasma nor CSF norepinephrine (NE) nor CSF 3-methoxy-4-hydroxyphenylgycol (MHPG) was significantly altered by carbamazepine. Baseline medication-free values in 21 depressed patients were not predictive of the degree of subsequent clinical antidepressant response. CSF NE decreased in four manic patients treated with carbamazepine. The many effects of carbamazepine on noradrenergic mechanisms in animals are discussed in relationship to these first studies of carbamazepine in man. 1432-2072 14322072 Springer |
| shingle_title_1 | Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients |
| shingle_title_2 | Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients |
| shingle_title_3 | Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients |
| shingle_title_4 | Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:44:10.540Z |
| titel | Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients |
| titel_suche | Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM200790773 |