Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur
| ISSN: |
1432-2072
|
|---|---|
| Keywords: |
Hypoglycemia ; Cognitive function ; Adaptation ; Type 1 diabetes ; Neuroglycopenia ; Symptoms of hypoglycemia
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295931980873729 |
|---|---|
| autor | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. |
| autorsonst | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. |
| book_url | http://dx.doi.org/10.1007/BF02246299 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM20072150X |
| issn | 1432-2072 |
| journal_name | Psychopharmacology |
| materialart | 1 |
| notes | Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time. |
| package_name | Springer |
| publikationsjahr_anzeige | 1995 |
| publikationsjahr_facette | 1995 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1995 |
| publisher | Springer |
| reference | 119 (1995), S. 325-333 |
| schlagwort | Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia |
| search_space | articles |
| shingle_author_1 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. |
| shingle_author_2 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. |
| shingle_author_3 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. |
| shingle_author_4 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. |
| shingle_catch_all_1 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time. 1432-2072 14322072 Springer |
| shingle_catch_all_2 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time. 1432-2072 14322072 Springer |
| shingle_catch_all_3 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time. 1432-2072 14322072 Springer |
| shingle_catch_all_4 | Gold, A. E. MacLeod, K. M. Thomson, K. J. Frier, B. M. Deary, I. J. Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Hypoglycemia Cognitive function Adaptation Type 1 diabetes Neuroglycopenia Symptoms of hypoglycemia Abstract It has been suggested that cerebral adaptation may occur in response to short-term hypoglycemia. This was examined in the present study by measuring serial changes in cognitive function and symptoms after 60 min of continuous hypoglycemia. Hypoglycemia was induced with a hyperinsulinemic glucose clamp on two separate occasions in 24 non-diabetic human subjects. Cognitive function was assessed using the following cognitive test battery: Paced Auditory Serial Addition Test (PASAT), Rapid Visual Information Processing (RVIP), Trail-Making B (TMB), Digit Symbol Substitution Test (DSST) and Four Choice Reaction Time (CRT). In condition A the blood glucose was maintained at 4.5 mmol/l throughout. On two separate occasions (condition B and condition C) the blood glucose was stabilised at 4.5 mmol/l for 30 min, lowered to 2.5 mmol/l for 60 min and restored to 4.5 mmol/l for 30 min. In each condition the cognitive test battery was performed immediately after stabilisation of blood glucose at 4.5 mmol/l and the subsequent battery was repeated at different time intervals: condition A — after a further 40 min of euglycemia; condition B — after 5 min of hypoglycemia; condition C — after 40 min of hypoglycemia. Acute hypoglycemia induced a significant deterioration in cognitive function which was manifest in all tests except TMB (P〈0.05), but performance ability did not differ between conditions B and C. Symptom scores, assessed by a scaled questionnaire, increased significantly during hypoglycemia (P〈0.001) but no differences were detected between the scores at 30 min and 60 min. In non-diabetic humans, no improvement appears to occur either in cognitive function or in symptom score after 40–60 min of hypoglycemia (2.5 mmol/l), suggesting that cerebral adaptation does not occur during this period of time. 1432-2072 14322072 Springer |
| shingle_title_1 | Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur |
| shingle_title_2 | Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur |
| shingle_title_3 | Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur |
| shingle_title_4 | Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:44:03.465Z |
| titel | Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur |
| titel_suche | Cognitive function during insulin-induced hypoglycemia in humans: Short-term cerebral adaptation does not occur |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM20072150X |