Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors
| ISSN: |
1432-2072
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| Keywords: |
Nitrous oxide ; Chlordiazepoxide ; Flumazenil ; Benzodiazepine receptors ; Elevated plus maze ; Mouse
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract In earlier research, we have hypothesized that exposure to nitrous oxide (N2O) produces an anxiolytic effect that is mediated by benzodiazepine (BZ) receptors. The present research was conducted to characterize pharmacologically the behavioral effects of N2O in comparison with a BZ standard, chlordiazepoxide (CP), in the mouse elevated plus maze. Exposure to increasing levels of N2O produced a concentration-related increase in the percent of total entries into and the percent of total time spent on the open arms, a pattern of response similar to that induced by CP. These effects of N2O and CP were both antagonized by pretreatment with the BZ receptor blocker flumazenil (FLU). In another experiment, mice made tolerant to CP also exhibited a cross-tolerance to N2O. These results support the hypothesis that the anxiolytic effect of N2O is mediated by BZ receptors.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295931377942529 |
|---|---|
| autor | Emmanouil, D. E. Johnson, C. H. Quock, R. M. |
| autorsonst | Emmanouil, D. E. Johnson, C. H. Quock, R. M. |
| book_url | http://dx.doi.org/10.1007/BF02244768 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM200718193 |
| issn | 1432-2072 |
| journal_name | Psychopharmacology |
| materialart | 1 |
| notes | Abstract In earlier research, we have hypothesized that exposure to nitrous oxide (N2O) produces an anxiolytic effect that is mediated by benzodiazepine (BZ) receptors. The present research was conducted to characterize pharmacologically the behavioral effects of N2O in comparison with a BZ standard, chlordiazepoxide (CP), in the mouse elevated plus maze. Exposure to increasing levels of N2O produced a concentration-related increase in the percent of total entries into and the percent of total time spent on the open arms, a pattern of response similar to that induced by CP. These effects of N2O and CP were both antagonized by pretreatment with the BZ receptor blocker flumazenil (FLU). In another experiment, mice made tolerant to CP also exhibited a cross-tolerance to N2O. These results support the hypothesis that the anxiolytic effect of N2O is mediated by BZ receptors. |
| package_name | Springer |
| publikationsjahr_anzeige | 1994 |
| publikationsjahr_facette | 1994 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1994 |
| publisher | Springer |
| reference | 115 (1994), S. 167-172 |
| schlagwort | Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse |
| search_space | articles |
| shingle_author_1 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. |
| shingle_author_2 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. |
| shingle_author_3 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. |
| shingle_author_4 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. |
| shingle_catch_all_1 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Abstract In earlier research, we have hypothesized that exposure to nitrous oxide (N2O) produces an anxiolytic effect that is mediated by benzodiazepine (BZ) receptors. The present research was conducted to characterize pharmacologically the behavioral effects of N2O in comparison with a BZ standard, chlordiazepoxide (CP), in the mouse elevated plus maze. Exposure to increasing levels of N2O produced a concentration-related increase in the percent of total entries into and the percent of total time spent on the open arms, a pattern of response similar to that induced by CP. These effects of N2O and CP were both antagonized by pretreatment with the BZ receptor blocker flumazenil (FLU). In another experiment, mice made tolerant to CP also exhibited a cross-tolerance to N2O. These results support the hypothesis that the anxiolytic effect of N2O is mediated by BZ receptors. 1432-2072 14322072 Springer |
| shingle_catch_all_2 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Abstract In earlier research, we have hypothesized that exposure to nitrous oxide (N2O) produces an anxiolytic effect that is mediated by benzodiazepine (BZ) receptors. The present research was conducted to characterize pharmacologically the behavioral effects of N2O in comparison with a BZ standard, chlordiazepoxide (CP), in the mouse elevated plus maze. Exposure to increasing levels of N2O produced a concentration-related increase in the percent of total entries into and the percent of total time spent on the open arms, a pattern of response similar to that induced by CP. These effects of N2O and CP were both antagonized by pretreatment with the BZ receptor blocker flumazenil (FLU). In another experiment, mice made tolerant to CP also exhibited a cross-tolerance to N2O. These results support the hypothesis that the anxiolytic effect of N2O is mediated by BZ receptors. 1432-2072 14322072 Springer |
| shingle_catch_all_3 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Abstract In earlier research, we have hypothesized that exposure to nitrous oxide (N2O) produces an anxiolytic effect that is mediated by benzodiazepine (BZ) receptors. The present research was conducted to characterize pharmacologically the behavioral effects of N2O in comparison with a BZ standard, chlordiazepoxide (CP), in the mouse elevated plus maze. Exposure to increasing levels of N2O produced a concentration-related increase in the percent of total entries into and the percent of total time spent on the open arms, a pattern of response similar to that induced by CP. These effects of N2O and CP were both antagonized by pretreatment with the BZ receptor blocker flumazenil (FLU). In another experiment, mice made tolerant to CP also exhibited a cross-tolerance to N2O. These results support the hypothesis that the anxiolytic effect of N2O is mediated by BZ receptors. 1432-2072 14322072 Springer |
| shingle_catch_all_4 | Emmanouil, D. E. Johnson, C. H. Quock, R. M. Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Nitrous oxide Chlordiazepoxide Flumazenil Benzodiazepine receptors Elevated plus maze Mouse Abstract In earlier research, we have hypothesized that exposure to nitrous oxide (N2O) produces an anxiolytic effect that is mediated by benzodiazepine (BZ) receptors. The present research was conducted to characterize pharmacologically the behavioral effects of N2O in comparison with a BZ standard, chlordiazepoxide (CP), in the mouse elevated plus maze. Exposure to increasing levels of N2O produced a concentration-related increase in the percent of total entries into and the percent of total time spent on the open arms, a pattern of response similar to that induced by CP. These effects of N2O and CP were both antagonized by pretreatment with the BZ receptor blocker flumazenil (FLU). In another experiment, mice made tolerant to CP also exhibited a cross-tolerance to N2O. These results support the hypothesis that the anxiolytic effect of N2O is mediated by BZ receptors. 1432-2072 14322072 Springer |
| shingle_title_1 | Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors |
| shingle_title_2 | Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors |
| shingle_title_3 | Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors |
| shingle_title_4 | Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:44:02.587Z |
| titel | Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors |
| titel_suche | Nitrous oxide anxiolytic effect in mice in the elevated plus maze: Mediation by benzodiazepine receptors |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM200718193 |