Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung
| ISSN: |
1432-0738
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|---|---|
| Keywords: |
NO2 ; SO2 ; AHH, Benzo(a)pyrene
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295497734094848 |
|---|---|
| autor | Husain, Mirza M. Dehnen, Walter |
| autorsonst | Husain, Mirza M. Dehnen, Walter |
| book_url | http://dx.doi.org/10.1007/BF00364652 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM200243977 |
| issn | 1432-0738 |
| journal_name | Archives of toxicology |
| materialart | 1 |
| notes | Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. |
| package_name | Springer |
| publikationsjahr_anzeige | 1978 |
| publikationsjahr_facette | 1978 |
| publikationsjahr_intervall | 8024:1975-1979 |
| publikationsjahr_sort | 1978 |
| publisher | Springer |
| reference | 40 (1978), S. 207-210 |
| schlagwort | NO2 SO2 AHH, Benzo(a)pyrene |
| search_space | articles |
| shingle_author_1 | Husain, Mirza M. Dehnen, Walter |
| shingle_author_2 | Husain, Mirza M. Dehnen, Walter |
| shingle_author_3 | Husain, Mirza M. Dehnen, Walter |
| shingle_author_4 | Husain, Mirza M. Dehnen, Walter |
| shingle_catch_all_1 | Husain, Mirza M. Dehnen, Walter Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung NO2 SO2 AHH, Benzo(a)pyrene NO2 SO2 AHH, Benzo(a)pyrene Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. 1432-0738 14320738 Springer |
| shingle_catch_all_2 | Husain, Mirza M. Dehnen, Walter Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung NO2 SO2 AHH, Benzo(a)pyrene NO2 SO2 AHH, Benzo(a)pyrene Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. 1432-0738 14320738 Springer |
| shingle_catch_all_3 | Husain, Mirza M. Dehnen, Walter Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung NO2 SO2 AHH, Benzo(a)pyrene NO2 SO2 AHH, Benzo(a)pyrene Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. 1432-0738 14320738 Springer |
| shingle_catch_all_4 | Husain, Mirza M. Dehnen, Walter Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung NO2 SO2 AHH, Benzo(a)pyrene NO2 SO2 AHH, Benzo(a)pyrene Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. 1432-0738 14320738 Springer |
| shingle_title_1 | Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
| shingle_title_2 | Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
| shingle_title_3 | Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
| shingle_title_4 | Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:37:08.693Z |
| titel | Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
| titel_suche | Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM200243977 |