Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans
Wildhirt, S. M. ; Weis, M. ; Schulze, C. ; Rieder, G. ; Enders, G. ; Wilbert-Lampen, U. ; Ueberfuhr, P. ; Reichenspurner, H. ; von Scheidt, W. ; Reichart, B.
Springer
Published 1998
Springer
Published 1998
| ISSN: |
1432-2277
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|---|---|
| Keywords: |
Key words Nitric oxide ; Endothelin ; Humans ; Heart transplantation ; Endothelial function
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
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| Notes: |
Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295973503434752 |
|---|---|
| autor | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. |
| autorsonst | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. |
| book_url | http://dx.doi.org/10.1007/s001470050532 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM200037757 |
| issn | 1432-2277 |
| journal_name | Transplant international |
| materialart | 1 |
| notes | Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy. |
| package_name | Springer |
| publikationsjahr_anzeige | 1998 |
| publikationsjahr_facette | 1998 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1998 |
| publisher | Springer |
| reference | 11 (1998), S. S519 |
| schlagwort | Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function |
| search_space | articles |
| shingle_author_1 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. |
| shingle_author_2 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. |
| shingle_author_3 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. |
| shingle_author_4 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. |
| shingle_catch_all_1 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy. 1432-2277 14322277 Springer |
| shingle_catch_all_2 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy. 1432-2277 14322277 Springer |
| shingle_catch_all_3 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy. 1432-2277 14322277 Springer |
| shingle_catch_all_4 | Wildhirt, S. M. Weis, M. Schulze, C. Rieder, G. Enders, G. Wilbert-Lampen, U. Ueberfuhr, P. Reichenspurner, H. von Scheidt, W. Reichart, B. Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Key words Nitric oxide Endothelin Humans Heart transplantation Endothelial function Abstract Endothelial dysfunction precedes and predicts transplant vasculopathy. We investigated the relationship between endothelial dysfunction and the vasoactive mediators nitric oxide and endothelin, 33.7 ± 2.0 days after heart transplantation. Coronary flow was measured in 18 patients to determine the endothelial microvascular vasomotor response to acetylcholine. Endomyocardial biopsies were taken to determine the levels of gene expression of isozymes of endothelin and nitric oxide synthases (NOS). Blood samples from the coronary sinus and aorta were withdrawn for measurement of endothelin, nitrite and cytokines. Five patients (30 %) showed an impaired coronary flow reserve response to acetylcholine, significantly higher inducible NOS gene expression and significant transcardiac nitrite production. Plasma nitrite correlated with tumour necrosis factor-alpha levels in coronary sinus and a transcardiac net extraction of endothelin was noted in all patients. In conclusion, 30 % of patients develop endothelial dysfunction early after heart transplantation; this correlates with the expression and activation of vasoactive and immunomodulatory mediators, which may predict the development of transplant vasculopathy. 1432-2277 14322277 Springer |
| shingle_title_1 | Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans |
| shingle_title_2 | Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans |
| shingle_title_3 | Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans |
| shingle_title_4 | Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:44:42.704Z |
| titel | Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans |
| titel_suche | Endothelium-dependent microvascular vasomotion and its correlation with vasoactive mediators early after cardiac transplantation in humans |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM200037757 |