Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults

ISSN:
1432-0428
Keywords:
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and antibodies to glutamic acid decarboxylase (GAD) (radio-immunoprecipitation) in 36 non-diabetic offspring (LADA-offspring) of patients with Type II (non-insulin-dependent) diabetes mellitus who tested positive for ICA and/or GAD antibodies during the 10-year follow-up from the diagnosis and in 19 healthy control subjects without a family history of diabetes.¶Results. The early insulin response during the first 10 min of an intravenous glucose tolerance test was about 40 % lower in the LADA-offspring than in the control group (p = 0.008). Insulin secretory capacity in the hyperglycaemic clamp was also about 30 % lower in the LADA-offspring (p = 0.048). The rates of whole body glucose uptake were similar in both groups. The frequency of low risk HLA-DQB1 genotypes was higher in the LADA-offspring than among Finnish healthy blood donors (p = 0.033). The risk conferring genotypes were associated with the lowest tertile of insulin secretory capacity in the LADA-offspring (p = 0.032). There were no associations between the autoantibodies and early insulin response or insulin secretory capacity within the study groups.¶Conclusion/interpretation. We conclude that LADA is a familial disease involving most likely gene defects leading to a slow progressive beta-cell destruction and insulin deficiency. [Diabetologia (2000) 43: 69–78]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001259900177
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autor Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
autorsonst Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
book_url http://dx.doi.org/10.1007/s001259900177
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM199947899
issn 1432-0428
journal_name Diabetologia
materialart 1
notes Abstract Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and antibodies to glutamic acid decarboxylase (GAD) (radio-immunoprecipitation) in 36 non-diabetic offspring (LADA-offspring) of patients with Type II (non-insulin-dependent) diabetes mellitus who tested positive for ICA and/or GAD antibodies during the 10-year follow-up from the diagnosis and in 19 healthy control subjects without a family history of diabetes.¶Results. The early insulin response during the first 10 min of an intravenous glucose tolerance test was about 40 % lower in the LADA-offspring than in the control group (p = 0.008). Insulin secretory capacity in the hyperglycaemic clamp was also about 30 % lower in the LADA-offspring (p = 0.048). The rates of whole body glucose uptake were similar in both groups. The frequency of low risk HLA-DQB1 genotypes was higher in the LADA-offspring than among Finnish healthy blood donors (p = 0.033). The risk conferring genotypes were associated with the lowest tertile of insulin secretory capacity in the LADA-offspring (p = 0.032). There were no associations between the autoantibodies and early insulin response or insulin secretory capacity within the study groups.¶Conclusion/interpretation. We conclude that LADA is a familial disease involving most likely gene defects leading to a slow progressive beta-cell destruction and insulin deficiency. [Diabetologia (2000) 43: 69–78]
package_name Springer
publikationsjahr_anzeige 2000
publikationsjahr_facette 2000
publikationsjahr_intervall 7999:2000-2004
publikationsjahr_sort 2000
publisher Springer
reference 43 (2000), S. 69-78
schlagwort Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
search_space articles
shingle_author_1 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
shingle_author_2 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
shingle_author_3 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
shingle_author_4 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
shingle_catch_all_1 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Abstract Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and antibodies to glutamic acid decarboxylase (GAD) (radio-immunoprecipitation) in 36 non-diabetic offspring (LADA-offspring) of patients with Type II (non-insulin-dependent) diabetes mellitus who tested positive for ICA and/or GAD antibodies during the 10-year follow-up from the diagnosis and in 19 healthy control subjects without a family history of diabetes.¶Results. The early insulin response during the first 10 min of an intravenous glucose tolerance test was about 40 % lower in the LADA-offspring than in the control group (p = 0.008). Insulin secretory capacity in the hyperglycaemic clamp was also about 30 % lower in the LADA-offspring (p = 0.048). The rates of whole body glucose uptake were similar in both groups. The frequency of low risk HLA-DQB1 genotypes was higher in the LADA-offspring than among Finnish healthy blood donors (p = 0.033). The risk conferring genotypes were associated with the lowest tertile of insulin secretory capacity in the LADA-offspring (p = 0.032). There were no associations between the autoantibodies and early insulin response or insulin secretory capacity within the study groups.¶Conclusion/interpretation. We conclude that LADA is a familial disease involving most likely gene defects leading to a slow progressive beta-cell destruction and insulin deficiency. [Diabetologia (2000) 43: 69–78]
1432-0428
14320428
Springer
shingle_catch_all_2 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Abstract Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and antibodies to glutamic acid decarboxylase (GAD) (radio-immunoprecipitation) in 36 non-diabetic offspring (LADA-offspring) of patients with Type II (non-insulin-dependent) diabetes mellitus who tested positive for ICA and/or GAD antibodies during the 10-year follow-up from the diagnosis and in 19 healthy control subjects without a family history of diabetes.¶Results. The early insulin response during the first 10 min of an intravenous glucose tolerance test was about 40 % lower in the LADA-offspring than in the control group (p = 0.008). Insulin secretory capacity in the hyperglycaemic clamp was also about 30 % lower in the LADA-offspring (p = 0.048). The rates of whole body glucose uptake were similar in both groups. The frequency of low risk HLA-DQB1 genotypes was higher in the LADA-offspring than among Finnish healthy blood donors (p = 0.033). The risk conferring genotypes were associated with the lowest tertile of insulin secretory capacity in the LADA-offspring (p = 0.032). There were no associations between the autoantibodies and early insulin response or insulin secretory capacity within the study groups.¶Conclusion/interpretation. We conclude that LADA is a familial disease involving most likely gene defects leading to a slow progressive beta-cell destruction and insulin deficiency. [Diabetologia (2000) 43: 69–78]
1432-0428
14320428
Springer
shingle_catch_all_3 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Abstract Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and antibodies to glutamic acid decarboxylase (GAD) (radio-immunoprecipitation) in 36 non-diabetic offspring (LADA-offspring) of patients with Type II (non-insulin-dependent) diabetes mellitus who tested positive for ICA and/or GAD antibodies during the 10-year follow-up from the diagnosis and in 19 healthy control subjects without a family history of diabetes.¶Results. The early insulin response during the first 10 min of an intravenous glucose tolerance test was about 40 % lower in the LADA-offspring than in the control group (p = 0.008). Insulin secretory capacity in the hyperglycaemic clamp was also about 30 % lower in the LADA-offspring (p = 0.048). The rates of whole body glucose uptake were similar in both groups. The frequency of low risk HLA-DQB1 genotypes was higher in the LADA-offspring than among Finnish healthy blood donors (p = 0.033). The risk conferring genotypes were associated with the lowest tertile of insulin secretory capacity in the LADA-offspring (p = 0.032). There were no associations between the autoantibodies and early insulin response or insulin secretory capacity within the study groups.¶Conclusion/interpretation. We conclude that LADA is a familial disease involving most likely gene defects leading to a slow progressive beta-cell destruction and insulin deficiency. [Diabetologia (2000) 43: 69–78]
1432-0428
14320428
Springer
shingle_catch_all_4 Vauhkonen, I.
Niskanen, L.
Knip, M.
Ilonen, J.
Vanninen, E.
Kainulainen, S.
Uusitupa, M.
Laakso, M.
Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Keywords Islet cell antibodies, glutamic acid decarboxylase antibodies, HLA-DQB1, relatives of Type II diabetic patients, insulin sensitivity.
Abstract Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and antibodies to glutamic acid decarboxylase (GAD) (radio-immunoprecipitation) in 36 non-diabetic offspring (LADA-offspring) of patients with Type II (non-insulin-dependent) diabetes mellitus who tested positive for ICA and/or GAD antibodies during the 10-year follow-up from the diagnosis and in 19 healthy control subjects without a family history of diabetes.¶Results. The early insulin response during the first 10 min of an intravenous glucose tolerance test was about 40 % lower in the LADA-offspring than in the control group (p = 0.008). Insulin secretory capacity in the hyperglycaemic clamp was also about 30 % lower in the LADA-offspring (p = 0.048). The rates of whole body glucose uptake were similar in both groups. The frequency of low risk HLA-DQB1 genotypes was higher in the LADA-offspring than among Finnish healthy blood donors (p = 0.033). The risk conferring genotypes were associated with the lowest tertile of insulin secretory capacity in the LADA-offspring (p = 0.032). There were no associations between the autoantibodies and early insulin response or insulin secretory capacity within the study groups.¶Conclusion/interpretation. We conclude that LADA is a familial disease involving most likely gene defects leading to a slow progressive beta-cell destruction and insulin deficiency. [Diabetologia (2000) 43: 69–78]
1432-0428
14320428
Springer
shingle_title_1 Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
shingle_title_2 Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
shingle_title_3 Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
shingle_title_4 Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
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timestamp 2024-05-06T09:35:19.224Z
titel Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
titel_suche Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults
topic WW-YZ
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