Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index

ISSN:
1432-0428
Keywords:
Keywords Autoimmunity ; beta-cell function ; BMI ; epidemiology ; sex ; glutamate decarboxylase ; IA-2 ; Type I and Type II diabetes ; OGTT.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedish subjects aged either 30, 40, 50 or 60 years old who, in 1988–1992, participated in the Västerbotten County Health Project and were subjected to the World Health Organisation (WHO) standard oral glucose tolerance test at entry into the study. Results. We found 23 of 2157 (1.1 %) and 17 of 2152 (0.8 %) subjects exceeded the 99th centile of GAD65 autoantibody index and IA-2 autoantibody index, respectively. In 18 subjects with diabetic oral glucose tolerance test, GAD65 autoantibody concentrations were higher than in those with normal oral glucose tolerance test (p = 0.02). Subjects with IGT (n = 416) and diabetes (n = 18), i. e. abnormal OGTT (n = 434), had a higher IA-2Ab index compared with those with normal OGTT (p = 0.008). A stepwise multiple logistic regression test showed that the odds ratios for subjects in the highest BMI group to exceed the 95th or 99th GAD65 autoantibody centile were 3.6 (CI 1.4–8.9) and 17.6 (CI 2.6–121.6), respectively. Conclusion/interpretation. GAD65 and IA-2 autoantibodies, are associated with impaired or diabetic glucose tolerance in an adult regional population. This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. [Diabetologia (1999) 42: 555–559]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001250051194
_version_ 1798295382535438338
autor Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
autorsonst Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
book_url http://dx.doi.org/10.1007/s001250051194
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM199946795
issn 1432-0428
journal_name Diabetologia
materialart 1
notes Abstract Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedish subjects aged either 30, 40, 50 or 60 years old who, in 1988–1992, participated in the Västerbotten County Health Project and were subjected to the World Health Organisation (WHO) standard oral glucose tolerance test at entry into the study. Results. We found 23 of 2157 (1.1 %) and 17 of 2152 (0.8 %) subjects exceeded the 99th centile of GAD65 autoantibody index and IA-2 autoantibody index, respectively. In 18 subjects with diabetic oral glucose tolerance test, GAD65 autoantibody concentrations were higher than in those with normal oral glucose tolerance test (p = 0.02). Subjects with IGT (n = 416) and diabetes (n = 18), i. e. abnormal OGTT (n = 434), had a higher IA-2Ab index compared with those with normal OGTT (p = 0.008). A stepwise multiple logistic regression test showed that the odds ratios for subjects in the highest BMI group to exceed the 95th or 99th GAD65 autoantibody centile were 3.6 (CI 1.4–8.9) and 17.6 (CI 2.6–121.6), respectively. Conclusion/interpretation. GAD65 and IA-2 autoantibodies, are associated with impaired or diabetic glucose tolerance in an adult regional population. This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. [Diabetologia (1999) 42: 555–559]
package_name Springer
publikationsjahr_anzeige 1999
publikationsjahr_facette 1999
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1999
publisher Springer
reference 42 (1999), S. 555-559
schlagwort Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
search_space articles
shingle_author_1 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
shingle_author_2 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
shingle_author_3 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
shingle_author_4 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
shingle_catch_all_1 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Abstract Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedish subjects aged either 30, 40, 50 or 60 years old who, in 1988–1992, participated in the Västerbotten County Health Project and were subjected to the World Health Organisation (WHO) standard oral glucose tolerance test at entry into the study. Results. We found 23 of 2157 (1.1 %) and 17 of 2152 (0.8 %) subjects exceeded the 99th centile of GAD65 autoantibody index and IA-2 autoantibody index, respectively. In 18 subjects with diabetic oral glucose tolerance test, GAD65 autoantibody concentrations were higher than in those with normal oral glucose tolerance test (p = 0.02). Subjects with IGT (n = 416) and diabetes (n = 18), i. e. abnormal OGTT (n = 434), had a higher IA-2Ab index compared with those with normal OGTT (p = 0.008). A stepwise multiple logistic regression test showed that the odds ratios for subjects in the highest BMI group to exceed the 95th or 99th GAD65 autoantibody centile were 3.6 (CI 1.4–8.9) and 17.6 (CI 2.6–121.6), respectively. Conclusion/interpretation. GAD65 and IA-2 autoantibodies, are associated with impaired or diabetic glucose tolerance in an adult regional population. This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. [Diabetologia (1999) 42: 555–559]
1432-0428
14320428
Springer
shingle_catch_all_2 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Abstract Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedish subjects aged either 30, 40, 50 or 60 years old who, in 1988–1992, participated in the Västerbotten County Health Project and were subjected to the World Health Organisation (WHO) standard oral glucose tolerance test at entry into the study. Results. We found 23 of 2157 (1.1 %) and 17 of 2152 (0.8 %) subjects exceeded the 99th centile of GAD65 autoantibody index and IA-2 autoantibody index, respectively. In 18 subjects with diabetic oral glucose tolerance test, GAD65 autoantibody concentrations were higher than in those with normal oral glucose tolerance test (p = 0.02). Subjects with IGT (n = 416) and diabetes (n = 18), i. e. abnormal OGTT (n = 434), had a higher IA-2Ab index compared with those with normal OGTT (p = 0.008). A stepwise multiple logistic regression test showed that the odds ratios for subjects in the highest BMI group to exceed the 95th or 99th GAD65 autoantibody centile were 3.6 (CI 1.4–8.9) and 17.6 (CI 2.6–121.6), respectively. Conclusion/interpretation. GAD65 and IA-2 autoantibodies, are associated with impaired or diabetic glucose tolerance in an adult regional population. This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. [Diabetologia (1999) 42: 555–559]
1432-0428
14320428
Springer
shingle_catch_all_3 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Abstract Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedish subjects aged either 30, 40, 50 or 60 years old who, in 1988–1992, participated in the Västerbotten County Health Project and were subjected to the World Health Organisation (WHO) standard oral glucose tolerance test at entry into the study. Results. We found 23 of 2157 (1.1 %) and 17 of 2152 (0.8 %) subjects exceeded the 99th centile of GAD65 autoantibody index and IA-2 autoantibody index, respectively. In 18 subjects with diabetic oral glucose tolerance test, GAD65 autoantibody concentrations were higher than in those with normal oral glucose tolerance test (p = 0.02). Subjects with IGT (n = 416) and diabetes (n = 18), i. e. abnormal OGTT (n = 434), had a higher IA-2Ab index compared with those with normal OGTT (p = 0.008). A stepwise multiple logistic regression test showed that the odds ratios for subjects in the highest BMI group to exceed the 95th or 99th GAD65 autoantibody centile were 3.6 (CI 1.4–8.9) and 17.6 (CI 2.6–121.6), respectively. Conclusion/interpretation. GAD65 and IA-2 autoantibodies, are associated with impaired or diabetic glucose tolerance in an adult regional population. This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. [Diabetologia (1999) 42: 555–559]
1432-0428
14320428
Springer
shingle_catch_all_4 Rolandsson, O.
Hägg, E.
Hampe, C.
Sullivan Jr., E. P.
Nilsson, M.
Jansson, G.
Hallmans, G.
Lernmark, Å.
Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Keywords Autoimmunity
beta-cell function
BMI
epidemiology
sex
glutamate decarboxylase
IA-2
Type I and Type II diabetes
OGTT.
Abstract Aims/hypothesis. Our aims were to investigate the concentrations and prevalence of autoantibodies against the Mr 65.000 isoform of glutamate decarboxylase (GAD65) and the tyrosine phosphatase-like protein (IA-2) in adults and to test the hypothesis that GAD65 and IA-2 autoantibodies in a regional population are related to abnormal oral glucose tolerance. Methods. We analysed serum from 2157 Swedish subjects aged either 30, 40, 50 or 60 years old who, in 1988–1992, participated in the Västerbotten County Health Project and were subjected to the World Health Organisation (WHO) standard oral glucose tolerance test at entry into the study. Results. We found 23 of 2157 (1.1 %) and 17 of 2152 (0.8 %) subjects exceeded the 99th centile of GAD65 autoantibody index and IA-2 autoantibody index, respectively. In 18 subjects with diabetic oral glucose tolerance test, GAD65 autoantibody concentrations were higher than in those with normal oral glucose tolerance test (p = 0.02). Subjects with IGT (n = 416) and diabetes (n = 18), i. e. abnormal OGTT (n = 434), had a higher IA-2Ab index compared with those with normal OGTT (p = 0.008). A stepwise multiple logistic regression test showed that the odds ratios for subjects in the highest BMI group to exceed the 95th or 99th GAD65 autoantibody centile were 3.6 (CI 1.4–8.9) and 17.6 (CI 2.6–121.6), respectively. Conclusion/interpretation. GAD65 and IA-2 autoantibodies, are associated with impaired or diabetic glucose tolerance in an adult regional population. This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. [Diabetologia (1999) 42: 555–559]
1432-0428
14320428
Springer
shingle_title_1 Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
shingle_title_2 Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
shingle_title_3 Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
shingle_title_4 Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:35:18.978Z
titel Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
titel_suche Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index
topic WW-YZ
uid nat_lic_papers_NLM199946795