Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM
Chowdhury, T. A. ; Dronsfield, M. J. ; Kumar, S. ; Gough, S. L. C. ; Gibson, S. P. ; Khatoon, A. ; MacDonald, F. ; Rowe, B. R. ; Dunger, D. B. ; Dean, J. D. ; Davies, S. J. ; Webber, J. ; Smith, P. R. ; Mackin, P. ; Marshall, S. M. ; Adu, D. ; Morris, P. J. M. ; Todd, J. A. ; Barnett, A. H. ; Boulton, A. J. M. ; Bain, S. C.
Springer
Published 1996
Springer
Published 1996
| ISSN: |
1432-0428
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|---|---|
| Keywords: |
Insulin-dependent diabetes mellitus ; polymerase chain reaction ; diabetic nephropathy ; angiotensinogen ; angiotensin converting enzyme ; gene polymorphism
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
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| Notes: |
Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295381236252673 |
|---|---|
| autor | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. |
| autorsonst | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. |
| book_url | http://dx.doi.org/10.1007/BF00400661 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM19993911X |
| issn | 1432-0428 |
| journal_name | Diabetologia |
| materialart | 1 |
| notes | Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom. |
| package_name | Springer |
| publikationsjahr_anzeige | 1996 |
| publikationsjahr_facette | 1996 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1996 |
| publisher | Springer |
| reference | 39 (1996), S. 1108-1114 |
| schlagwort | Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism |
| search_space | articles |
| shingle_author_1 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. |
| shingle_author_2 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. |
| shingle_author_3 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. |
| shingle_author_4 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. |
| shingle_catch_all_1 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom. 1432-0428 14320428 Springer |
| shingle_catch_all_2 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom. 1432-0428 14320428 Springer |
| shingle_catch_all_3 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom. 1432-0428 14320428 Springer |
| shingle_catch_all_4 | Chowdhury, T. A. Dronsfield, M. J. Kumar, S. Gough, S. L. C. Gibson, S. P. Khatoon, A. MacDonald, F. Rowe, B. R. Dunger, D. B. Dean, J. D. Davies, S. J. Webber, J. Smith, P. R. Mackin, P. Marshall, S. M. Adu, D. Morris, P. J. M. Todd, J. A. Barnett, A. H. Boulton, A. J. M. Bain, S. C. Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Insulin-dependent diabetes mellitus polymerase chain reaction diabetic nephropathy angiotensinogen angiotensin converting enzyme gene polymorphism Summary Premature cardiovascular disease is common in insulin-dependent diabetic (IDDM) patients who develop diabetic nephropathy. Genetic polymorphism within the renin-angiotensin system has been implicated in the aetiology of a number of cardiovascular disorders; these loci are therefore candidate genes for susceptibility to diabetic renal disease. We have examined the angiotensin converting enzyme insertion/deletion polymorphism and angiotensinogen methionine 235 threonine polymorphism in a large cohort of Caucasian patients with IDDM and diabetic nephropathy. Patients were classified as having nephropathy by the presence of persistent dipstick positive proteinuria (in the absence of other causes), retinopathy and hypertension (n=242). Three groups were examined for comparison: ethnically matched non-diabetic subjects (n=187); a geographically defined cohort of newly diagnosed diabetic patients (n=341); and IDDM patients with long duration of disease (〉15 years) and no evidence of overt nephropathy (n=166). No significant difference was seen in distribution of angiotensin converting enzyme or angiotensinogen genotypes between IDDM patients with nephropathy and recently diagnosed diabetic subjects (p=0.282 and 0.584, respectively), nor the long-duration non-nephropathy diabetic subjects (p=0.701 and 0.190, respectively). We conclude that these genetic loci are unlikely to influence susceptibility to diabetic nephropathy in IDDM in the United Kingdom. 1432-0428 14320428 Springer |
| shingle_title_1 | Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM |
| shingle_title_2 | Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM |
| shingle_title_3 | Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM |
| shingle_title_4 | Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:18.010Z |
| titel | Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM |
| titel_suche | Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM19993911X |