Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men

ISSN:
1432-0428
Keywords:
Key words Diabetes mellitus ; glucose intolerance ; insulin ; cognition ; aged ; epidemiology.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00402181
_version_ 1798295380902805504
autor Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
autorsonst Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
book_url http://dx.doi.org/10.1007/BF00402181
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM199935408
issn 1432-0428
journal_name Diabetologia
materialart 1
notes Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
package_name Springer
publikationsjahr_anzeige 1995
publikationsjahr_facette 1995
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1995
publisher Springer
reference 38 (1995), S. 1096-1102
schlagwort Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
search_space articles
shingle_author_1 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
shingle_author_2 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
shingle_author_3 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
shingle_author_4 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
shingle_catch_all_1 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
1432-0428
14320428
Springer
shingle_catch_all_2 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
1432-0428
14320428
Springer
shingle_catch_all_3 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
1432-0428
14320428
Springer
shingle_catch_all_4 Kalmijn, S.
Feskens, E. J. M.
Launer, L. J.
Stijnen, T.
Kromhout, D.
Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Key words Diabetes mellitus
glucose intolerance
insulin
cognition
aged
epidemiology.
Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
1432-0428
14320428
Springer
shingle_title_1 Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
shingle_title_2 Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
shingle_title_3 Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
shingle_title_4 Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:35:18.010Z
titel Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
titel_suche Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
topic WW-YZ
uid nat_lic_papers_NLM199935408