The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study

ISSN:
1432-0428
Keywords:
Key words Insulin ; longitudinal ; clustering ; children ; adolescents ; serum lipoproteins ; blood pressure.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In adults hyperinsulinaemia is associated with an atherogenic risk profile including obesity, low levels of HDL-cholesterol, high levels of triglycerides and elevated blood pressure. To examine these associations in the young we studied the cross-sectional relationships of insulin with obesity indices (body mass index, subscapular skinfold thickness), serum lipids and blood pressure in 1,865 children, adolescents and young adults aged 6–24 years. We also used longitudinal data to study the value of a single insulin measurement to predict high risk factor levels and clustering of multiple risk factors after a 6-year follow-up. In cross-sectional analyses the levels of triglycerides, HDL-cholesterol, systolic blood pressure and obesity indices were usually significantly different across the quartiles of fasting insulin in both sexes among children, adolescents and young adults. In general, no associations were seen with total cholesterol or LDL-cholesterol. In prospective analysis elevated baseline insulin was related to the incidence of hypertriglyceridaemia (≥ 95th percentile) at the follow-up. This relationship persisted even after adjustments for baseline obesity or 6-year change in obesity status. Moreover, baseline insulin concentration was higher in subjects who subsequently showed clustering of high triglycerides, low HDL-cholesterol and high systolic blood pressure levels at the follow-up. We conclude that high fasting insulin levels measured in children and adolescents predict the development of hypertriglyceridaemia years later. In addition, high insulin levels seem to precede the development of a potentially atherogenic risk factor profile including low HDL-cholesterol, high triglycerides and high systolic blood pressure. [Diabetologia (1995) 38: 1042–1050]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00402173
_version_ 1798295380887076865
autor Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
autorsonst Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
book_url http://dx.doi.org/10.1007/BF00402173
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM199935327
issn 1432-0428
journal_name Diabetologia
materialart 1
notes Summary In adults hyperinsulinaemia is associated with an atherogenic risk profile including obesity, low levels of HDL-cholesterol, high levels of triglycerides and elevated blood pressure. To examine these associations in the young we studied the cross-sectional relationships of insulin with obesity indices (body mass index, subscapular skinfold thickness), serum lipids and blood pressure in 1,865 children, adolescents and young adults aged 6–24 years. We also used longitudinal data to study the value of a single insulin measurement to predict high risk factor levels and clustering of multiple risk factors after a 6-year follow-up. In cross-sectional analyses the levels of triglycerides, HDL-cholesterol, systolic blood pressure and obesity indices were usually significantly different across the quartiles of fasting insulin in both sexes among children, adolescents and young adults. In general, no associations were seen with total cholesterol or LDL-cholesterol. In prospective analysis elevated baseline insulin was related to the incidence of hypertriglyceridaemia (≥ 95th percentile) at the follow-up. This relationship persisted even after adjustments for baseline obesity or 6-year change in obesity status. Moreover, baseline insulin concentration was higher in subjects who subsequently showed clustering of high triglycerides, low HDL-cholesterol and high systolic blood pressure levels at the follow-up. We conclude that high fasting insulin levels measured in children and adolescents predict the development of hypertriglyceridaemia years later. In addition, high insulin levels seem to precede the development of a potentially atherogenic risk factor profile including low HDL-cholesterol, high triglycerides and high systolic blood pressure. [Diabetologia (1995) 38: 1042–1050]
package_name Springer
publikationsjahr_anzeige 1995
publikationsjahr_facette 1995
publikationsjahr_intervall 8004:1995-1999
publikationsjahr_sort 1995
publisher Springer
reference 38 (1995), S. 1042-1050
schlagwort Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
search_space articles
shingle_author_1 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
shingle_author_2 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
shingle_author_3 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
shingle_author_4 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
shingle_catch_all_1 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Summary In adults hyperinsulinaemia is associated with an atherogenic risk profile including obesity, low levels of HDL-cholesterol, high levels of triglycerides and elevated blood pressure. To examine these associations in the young we studied the cross-sectional relationships of insulin with obesity indices (body mass index, subscapular skinfold thickness), serum lipids and blood pressure in 1,865 children, adolescents and young adults aged 6–24 years. We also used longitudinal data to study the value of a single insulin measurement to predict high risk factor levels and clustering of multiple risk factors after a 6-year follow-up. In cross-sectional analyses the levels of triglycerides, HDL-cholesterol, systolic blood pressure and obesity indices were usually significantly different across the quartiles of fasting insulin in both sexes among children, adolescents and young adults. In general, no associations were seen with total cholesterol or LDL-cholesterol. In prospective analysis elevated baseline insulin was related to the incidence of hypertriglyceridaemia (≥ 95th percentile) at the follow-up. This relationship persisted even after adjustments for baseline obesity or 6-year change in obesity status. Moreover, baseline insulin concentration was higher in subjects who subsequently showed clustering of high triglycerides, low HDL-cholesterol and high systolic blood pressure levels at the follow-up. We conclude that high fasting insulin levels measured in children and adolescents predict the development of hypertriglyceridaemia years later. In addition, high insulin levels seem to precede the development of a potentially atherogenic risk factor profile including low HDL-cholesterol, high triglycerides and high systolic blood pressure. [Diabetologia (1995) 38: 1042–1050]
1432-0428
14320428
Springer
shingle_catch_all_2 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Summary In adults hyperinsulinaemia is associated with an atherogenic risk profile including obesity, low levels of HDL-cholesterol, high levels of triglycerides and elevated blood pressure. To examine these associations in the young we studied the cross-sectional relationships of insulin with obesity indices (body mass index, subscapular skinfold thickness), serum lipids and blood pressure in 1,865 children, adolescents and young adults aged 6–24 years. We also used longitudinal data to study the value of a single insulin measurement to predict high risk factor levels and clustering of multiple risk factors after a 6-year follow-up. In cross-sectional analyses the levels of triglycerides, HDL-cholesterol, systolic blood pressure and obesity indices were usually significantly different across the quartiles of fasting insulin in both sexes among children, adolescents and young adults. In general, no associations were seen with total cholesterol or LDL-cholesterol. In prospective analysis elevated baseline insulin was related to the incidence of hypertriglyceridaemia (≥ 95th percentile) at the follow-up. This relationship persisted even after adjustments for baseline obesity or 6-year change in obesity status. Moreover, baseline insulin concentration was higher in subjects who subsequently showed clustering of high triglycerides, low HDL-cholesterol and high systolic blood pressure levels at the follow-up. We conclude that high fasting insulin levels measured in children and adolescents predict the development of hypertriglyceridaemia years later. In addition, high insulin levels seem to precede the development of a potentially atherogenic risk factor profile including low HDL-cholesterol, high triglycerides and high systolic blood pressure. [Diabetologia (1995) 38: 1042–1050]
1432-0428
14320428
Springer
shingle_catch_all_3 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Summary In adults hyperinsulinaemia is associated with an atherogenic risk profile including obesity, low levels of HDL-cholesterol, high levels of triglycerides and elevated blood pressure. To examine these associations in the young we studied the cross-sectional relationships of insulin with obesity indices (body mass index, subscapular skinfold thickness), serum lipids and blood pressure in 1,865 children, adolescents and young adults aged 6–24 years. We also used longitudinal data to study the value of a single insulin measurement to predict high risk factor levels and clustering of multiple risk factors after a 6-year follow-up. In cross-sectional analyses the levels of triglycerides, HDL-cholesterol, systolic blood pressure and obesity indices were usually significantly different across the quartiles of fasting insulin in both sexes among children, adolescents and young adults. In general, no associations were seen with total cholesterol or LDL-cholesterol. In prospective analysis elevated baseline insulin was related to the incidence of hypertriglyceridaemia (≥ 95th percentile) at the follow-up. This relationship persisted even after adjustments for baseline obesity or 6-year change in obesity status. Moreover, baseline insulin concentration was higher in subjects who subsequently showed clustering of high triglycerides, low HDL-cholesterol and high systolic blood pressure levels at the follow-up. We conclude that high fasting insulin levels measured in children and adolescents predict the development of hypertriglyceridaemia years later. In addition, high insulin levels seem to precede the development of a potentially atherogenic risk factor profile including low HDL-cholesterol, high triglycerides and high systolic blood pressure. [Diabetologia (1995) 38: 1042–1050]
1432-0428
14320428
Springer
shingle_catch_all_4 Raitakari, O. T.
Porkka, K. V. K.
Rönnemaa, T.
Knip, M.
Uhari, M.
Åkerblom, H. K.
Viikari, J. S. A.
The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Key words Insulin
longitudinal
clustering
children
adolescents
serum lipoproteins
blood pressure.
Summary In adults hyperinsulinaemia is associated with an atherogenic risk profile including obesity, low levels of HDL-cholesterol, high levels of triglycerides and elevated blood pressure. To examine these associations in the young we studied the cross-sectional relationships of insulin with obesity indices (body mass index, subscapular skinfold thickness), serum lipids and blood pressure in 1,865 children, adolescents and young adults aged 6–24 years. We also used longitudinal data to study the value of a single insulin measurement to predict high risk factor levels and clustering of multiple risk factors after a 6-year follow-up. In cross-sectional analyses the levels of triglycerides, HDL-cholesterol, systolic blood pressure and obesity indices were usually significantly different across the quartiles of fasting insulin in both sexes among children, adolescents and young adults. In general, no associations were seen with total cholesterol or LDL-cholesterol. In prospective analysis elevated baseline insulin was related to the incidence of hypertriglyceridaemia (≥ 95th percentile) at the follow-up. This relationship persisted even after adjustments for baseline obesity or 6-year change in obesity status. Moreover, baseline insulin concentration was higher in subjects who subsequently showed clustering of high triglycerides, low HDL-cholesterol and high systolic blood pressure levels at the follow-up. We conclude that high fasting insulin levels measured in children and adolescents predict the development of hypertriglyceridaemia years later. In addition, high insulin levels seem to precede the development of a potentially atherogenic risk factor profile including low HDL-cholesterol, high triglycerides and high systolic blood pressure. [Diabetologia (1995) 38: 1042–1050]
1432-0428
14320428
Springer
shingle_title_1 The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
shingle_title_2 The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
shingle_title_3 The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
shingle_title_4 The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
sigel_instance_filter dkfz
geomar
wilbert
ipn
albert
fhp
source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:35:18.010Z
titel The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
titel_suche The role of insulin in clustering of serum lipids and blood pressure in children and adolescents The Cardiovascular Risk in Young Finns Study
topic WW-YZ
uid nat_lic_papers_NLM199935327