Linkage studies in NIDDM with markers near the sulphonylurea receptor gene
Stirling, B. ; Cox, N. J. ; Bell, G. I. ; Hanis, C. L. ; Spielman, R. S. ; Concannon, P.
Springer
Published 1995
Springer
Published 1995
| ISSN: |
1432-0428
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|---|---|
| Keywords: |
Sulphonylurea receptor ; non-insulin-dependent diabetes mellitus ; genetics ; polymorphism ; linkage mapping
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Summary The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in non-insulin-dependent diabetes mellitus (NIDDM) through linkage studies with microsatellite markers tightly linked to the SUR gene. The microsatellite markers were typed in 346 Mexican-American NIDDM affected sib pairs derived from 176 families and an additional 110 ethnically and geographically matched control subjects. No evidence of linkage, based on allele sharing, or association based on allele frequencies in patients and control subjects, for any microsatellite marker and NIDDM was observed in this population. These results suggest that genetic variation in the SUR gene does not play a major role in susceptibility to NIDDM in the Mexican-American population.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798295380525318144 |
|---|---|
| autor | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. |
| autorsonst | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. |
| book_url | http://dx.doi.org/10.1007/BF00400610 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM199932409 |
| issn | 1432-0428 |
| journal_name | Diabetologia |
| materialart | 1 |
| notes | Summary The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in non-insulin-dependent diabetes mellitus (NIDDM) through linkage studies with microsatellite markers tightly linked to the SUR gene. The microsatellite markers were typed in 346 Mexican-American NIDDM affected sib pairs derived from 176 families and an additional 110 ethnically and geographically matched control subjects. No evidence of linkage, based on allele sharing, or association based on allele frequencies in patients and control subjects, for any microsatellite marker and NIDDM was observed in this population. These results suggest that genetic variation in the SUR gene does not play a major role in susceptibility to NIDDM in the Mexican-American population. |
| package_name | Springer |
| publikationsjahr_anzeige | 1995 |
| publikationsjahr_facette | 1995 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1995 |
| publisher | Springer |
| reference | 38 (1995), S. 1479-1481 |
| schlagwort | Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping |
| search_space | articles |
| shingle_author_1 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. |
| shingle_author_2 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. |
| shingle_author_3 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. |
| shingle_author_4 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. |
| shingle_catch_all_1 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Summary The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in non-insulin-dependent diabetes mellitus (NIDDM) through linkage studies with microsatellite markers tightly linked to the SUR gene. The microsatellite markers were typed in 346 Mexican-American NIDDM affected sib pairs derived from 176 families and an additional 110 ethnically and geographically matched control subjects. No evidence of linkage, based on allele sharing, or association based on allele frequencies in patients and control subjects, for any microsatellite marker and NIDDM was observed in this population. These results suggest that genetic variation in the SUR gene does not play a major role in susceptibility to NIDDM in the Mexican-American population. 1432-0428 14320428 Springer |
| shingle_catch_all_2 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Summary The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in non-insulin-dependent diabetes mellitus (NIDDM) through linkage studies with microsatellite markers tightly linked to the SUR gene. The microsatellite markers were typed in 346 Mexican-American NIDDM affected sib pairs derived from 176 families and an additional 110 ethnically and geographically matched control subjects. No evidence of linkage, based on allele sharing, or association based on allele frequencies in patients and control subjects, for any microsatellite marker and NIDDM was observed in this population. These results suggest that genetic variation in the SUR gene does not play a major role in susceptibility to NIDDM in the Mexican-American population. 1432-0428 14320428 Springer |
| shingle_catch_all_3 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Summary The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in non-insulin-dependent diabetes mellitus (NIDDM) through linkage studies with microsatellite markers tightly linked to the SUR gene. The microsatellite markers were typed in 346 Mexican-American NIDDM affected sib pairs derived from 176 families and an additional 110 ethnically and geographically matched control subjects. No evidence of linkage, based on allele sharing, or association based on allele frequencies in patients and control subjects, for any microsatellite marker and NIDDM was observed in this population. These results suggest that genetic variation in the SUR gene does not play a major role in susceptibility to NIDDM in the Mexican-American population. 1432-0428 14320428 Springer |
| shingle_catch_all_4 | Stirling, B. Cox, N. J. Bell, G. I. Hanis, C. L. Spielman, R. S. Concannon, P. Linkage studies in NIDDM with markers near the sulphonylurea receptor gene Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Sulphonylurea receptor non-insulin-dependent diabetes mellitus genetics polymorphism linkage mapping Summary The high affinity receptor for sulphonylureas, expressed on the beta cells of the pancreas, plays a crucial role in the control of insulin secretion. Mutations in the cytoplasmic domain of the sulphonylurea receptor (SUR) gene that disrupt the regulation of insulin secretion have been previously described. In the present study, the potential role of genetic variation in the SUR gene has been investigated in non-insulin-dependent diabetes mellitus (NIDDM) through linkage studies with microsatellite markers tightly linked to the SUR gene. The microsatellite markers were typed in 346 Mexican-American NIDDM affected sib pairs derived from 176 families and an additional 110 ethnically and geographically matched control subjects. No evidence of linkage, based on allele sharing, or association based on allele frequencies in patients and control subjects, for any microsatellite marker and NIDDM was observed in this population. These results suggest that genetic variation in the SUR gene does not play a major role in susceptibility to NIDDM in the Mexican-American population. 1432-0428 14320428 Springer |
| shingle_title_1 | Linkage studies in NIDDM with markers near the sulphonylurea receptor gene |
| shingle_title_2 | Linkage studies in NIDDM with markers near the sulphonylurea receptor gene |
| shingle_title_3 | Linkage studies in NIDDM with markers near the sulphonylurea receptor gene |
| shingle_title_4 | Linkage studies in NIDDM with markers near the sulphonylurea receptor gene |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:35:17.183Z |
| titel | Linkage studies in NIDDM with markers near the sulphonylurea receptor gene |
| titel_suche | Linkage studies in NIDDM with markers near the sulphonylurea receptor gene |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM199932409 |