Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation

ISSN:
1432-0428
Keywords:
Pancreas transplantation ; Kidney transplantation ; Diabetic neuropathy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 diabetic uraemic patients with combined pancreas and kidney transplantation were compared to 9 diabetic patients with a renal graft only. Neurophysiological studies of peripheral neuropathy included ulnar and deep peroneal nerve motor conduction velocity, median and sural nerve sensory conduction velocity were performed at baseline and 1 and 2 years after transplantation. One year after transplantation mean nerve conduction velocity significantly improved in both groups. However, changes were statistically significant in the kidney-pancreas group only. At the 2 year follow-up nerve conduction velocity had increased further in the pancreas-kidney group only. These data suggest that improvement of nerve conduction velocity following pancreas and kidney transplantation is predominantly due to the long-term euglycaemic state.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295379242909696
autor Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
autorsonst Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
book_url http://dx.doi.org/10.1007/BF00587632
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM19992189X
issn 1432-0428
journal_name Diabetologia
materialart 1
notes Summary Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 diabetic uraemic patients with combined pancreas and kidney transplantation were compared to 9 diabetic patients with a renal graft only. Neurophysiological studies of peripheral neuropathy included ulnar and deep peroneal nerve motor conduction velocity, median and sural nerve sensory conduction velocity were performed at baseline and 1 and 2 years after transplantation. One year after transplantation mean nerve conduction velocity significantly improved in both groups. However, changes were statistically significant in the kidney-pancreas group only. At the 2 year follow-up nerve conduction velocity had increased further in the pancreas-kidney group only. These data suggest that improvement of nerve conduction velocity following pancreas and kidney transplantation is predominantly due to the long-term euglycaemic state.
package_name Springer
publikationsjahr_anzeige 1991
publikationsjahr_facette 1991
publikationsjahr_intervall 8009:1990-1994
publikationsjahr_sort 1991
publisher Springer
reference 34 (1991), S. S103
schlagwort Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
search_space articles
shingle_author_1 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
shingle_author_2 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
shingle_author_3 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
shingle_author_4 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
shingle_catch_all_1 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Summary Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 diabetic uraemic patients with combined pancreas and kidney transplantation were compared to 9 diabetic patients with a renal graft only. Neurophysiological studies of peripheral neuropathy included ulnar and deep peroneal nerve motor conduction velocity, median and sural nerve sensory conduction velocity were performed at baseline and 1 and 2 years after transplantation. One year after transplantation mean nerve conduction velocity significantly improved in both groups. However, changes were statistically significant in the kidney-pancreas group only. At the 2 year follow-up nerve conduction velocity had increased further in the pancreas-kidney group only. These data suggest that improvement of nerve conduction velocity following pancreas and kidney transplantation is predominantly due to the long-term euglycaemic state.
1432-0428
14320428
Springer
shingle_catch_all_2 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Summary Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 diabetic uraemic patients with combined pancreas and kidney transplantation were compared to 9 diabetic patients with a renal graft only. Neurophysiological studies of peripheral neuropathy included ulnar and deep peroneal nerve motor conduction velocity, median and sural nerve sensory conduction velocity were performed at baseline and 1 and 2 years after transplantation. One year after transplantation mean nerve conduction velocity significantly improved in both groups. However, changes were statistically significant in the kidney-pancreas group only. At the 2 year follow-up nerve conduction velocity had increased further in the pancreas-kidney group only. These data suggest that improvement of nerve conduction velocity following pancreas and kidney transplantation is predominantly due to the long-term euglycaemic state.
1432-0428
14320428
Springer
shingle_catch_all_3 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Summary Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 diabetic uraemic patients with combined pancreas and kidney transplantation were compared to 9 diabetic patients with a renal graft only. Neurophysiological studies of peripheral neuropathy included ulnar and deep peroneal nerve motor conduction velocity, median and sural nerve sensory conduction velocity were performed at baseline and 1 and 2 years after transplantation. One year after transplantation mean nerve conduction velocity significantly improved in both groups. However, changes were statistically significant in the kidney-pancreas group only. At the 2 year follow-up nerve conduction velocity had increased further in the pancreas-kidney group only. These data suggest that improvement of nerve conduction velocity following pancreas and kidney transplantation is predominantly due to the long-term euglycaemic state.
1432-0428
14320428
Springer
shingle_catch_all_4 Comi, G.
Galardi, G.
Amadio, S.
Bianchi, E.
Secchi, A.
Martinenghi, S.
Caldara, R.
Pozza, G.
Canal, N.
Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Pancreas transplantation
Kidney transplantation
Diabetic neuropathy
Summary Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 diabetic uraemic patients with combined pancreas and kidney transplantation were compared to 9 diabetic patients with a renal graft only. Neurophysiological studies of peripheral neuropathy included ulnar and deep peroneal nerve motor conduction velocity, median and sural nerve sensory conduction velocity were performed at baseline and 1 and 2 years after transplantation. One year after transplantation mean nerve conduction velocity significantly improved in both groups. However, changes were statistically significant in the kidney-pancreas group only. At the 2 year follow-up nerve conduction velocity had increased further in the pancreas-kidney group only. These data suggest that improvement of nerve conduction velocity following pancreas and kidney transplantation is predominantly due to the long-term euglycaemic state.
1432-0428
14320428
Springer
shingle_title_1 Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
shingle_title_2 Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
shingle_title_3 Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
shingle_title_4 Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
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timestamp 2024-05-06T09:35:15.458Z
titel Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
titel_suche Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation
topic WW-YZ
uid nat_lic_papers_NLM19992189X