Interaction of HLA and immunoglobulin antigens in Type 1 (insulin-dependent) diabetes
Field, L. L. ; Andersen, C. E. ; Neiswanger, K. ; Hodge, S. E. ; Spence, M. A. ; Rotter, J. I.
Springer
Published 1984
Springer
Published 1984
| ISSN: |
1432-0428
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|---|---|
| Keywords: |
Type 1 diabetes ; immunoglobulin allotypes ; HLA ; GM ; KM ; INV ; disease marker ; genetic linkage
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Summary We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 diabetes (significant or of borderline significance after considering the effect of multiple tests): possession of Glm(2) appeared to increase susceptibility to diabetes in individuals who had HLA-DR3 but not HLA-DR4, while possession of G3m(5) appeared to increase susceptibility in individuals who had HLA-DR4 but not HLA-DR3. These results suggest that genetic predisposition to Type 1 diabetes is partially determined by alleles at the GM locus (or a locus in linkage disequilibrium with GM) interacting with alleles at the HLA-DR locus (or a locus in linkage disequilibrium with HLA-DR).
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| Type of Medium: |
Electronic Resource
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| URL: |