Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines

Lebowitz, R. J. ; Soller, M. ; Beckmann, J. S.
Springer
Published 1987
ISSN:
1432-2242
Keywords:
Quantitative trait ; Genetic markers ; QTL ; Linkage analysis ; QTL mapping
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in selection lines derived from the F-2 of a cross between inbred lines, or in the “high” and “low” phenotypic classes of an F-2 or BC population. The power of such trait-based (TB) analyses was evaluated and compared with that of methods for determining linkage based on the mean quantitative trait value of marker genotypes in F-2 or BC populations [marker-based (MB) analyses]. TB analyses can be utilized for marker-QTL linkage determination in situations where the MB analysis is not applicable, including analysis of polygenic resistance traits where only a part of the population survives exposure to the Stressor and analysis of marker-allele frequency changes in selection lines. TB analyses may be a useful alternative to MB analyses when interest is centered on a single quantitative trait only and costs of scoring for markers are high compared with costs of raising and obtaining quantitative trait information on F-2 or BC individuals. In this case, a TB analysis will enable equivalent power to be obtained with fewer individuals scored for the marker, but more individuals scored for the quantitative trait. MB analyses remain the method of choice when more than one quantitative trait is to be analyzed in a given population.
Type of Medium:
Electronic Resource
URL:
_version_ 1798295967749898240
autor Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
autorsonst Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
book_url http://dx.doi.org/10.1007/BF00289194
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM199844445
iqvoc_descriptor_keyword iqvoc_00000708:analysis
issn 1432-2242
journal_name Theoretical and applied genetics
materialart 1
notes Summary Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in selection lines derived from the F-2 of a cross between inbred lines, or in the “high” and “low” phenotypic classes of an F-2 or BC population. The power of such trait-based (TB) analyses was evaluated and compared with that of methods for determining linkage based on the mean quantitative trait value of marker genotypes in F-2 or BC populations [marker-based (MB) analyses]. TB analyses can be utilized for marker-QTL linkage determination in situations where the MB analysis is not applicable, including analysis of polygenic resistance traits where only a part of the population survives exposure to the Stressor and analysis of marker-allele frequency changes in selection lines. TB analyses may be a useful alternative to MB analyses when interest is centered on a single quantitative trait only and costs of scoring for markers are high compared with costs of raising and obtaining quantitative trait information on F-2 or BC individuals. In this case, a TB analysis will enable equivalent power to be obtained with fewer individuals scored for the marker, but more individuals scored for the quantitative trait. MB analyses remain the method of choice when more than one quantitative trait is to be analyzed in a given population.
package_name Springer
publikationsjahr_anzeige 1987
publikationsjahr_facette 1987
publikationsjahr_intervall 8014:1985-1989
publikationsjahr_sort 1987
publisher Springer
reference 73 (1987), S. 556-562
schlagwort Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
search_space articles
shingle_author_1 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
shingle_author_2 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
shingle_author_3 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
shingle_author_4 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
shingle_catch_all_1 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Summary Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in selection lines derived from the F-2 of a cross between inbred lines, or in the “high” and “low” phenotypic classes of an F-2 or BC population. The power of such trait-based (TB) analyses was evaluated and compared with that of methods for determining linkage based on the mean quantitative trait value of marker genotypes in F-2 or BC populations [marker-based (MB) analyses]. TB analyses can be utilized for marker-QTL linkage determination in situations where the MB analysis is not applicable, including analysis of polygenic resistance traits where only a part of the population survives exposure to the Stressor and analysis of marker-allele frequency changes in selection lines. TB analyses may be a useful alternative to MB analyses when interest is centered on a single quantitative trait only and costs of scoring for markers are high compared with costs of raising and obtaining quantitative trait information on F-2 or BC individuals. In this case, a TB analysis will enable equivalent power to be obtained with fewer individuals scored for the marker, but more individuals scored for the quantitative trait. MB analyses remain the method of choice when more than one quantitative trait is to be analyzed in a given population.
1432-2242
14322242
Springer
shingle_catch_all_2 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Summary Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in selection lines derived from the F-2 of a cross between inbred lines, or in the “high” and “low” phenotypic classes of an F-2 or BC population. The power of such trait-based (TB) analyses was evaluated and compared with that of methods for determining linkage based on the mean quantitative trait value of marker genotypes in F-2 or BC populations [marker-based (MB) analyses]. TB analyses can be utilized for marker-QTL linkage determination in situations where the MB analysis is not applicable, including analysis of polygenic resistance traits where only a part of the population survives exposure to the Stressor and analysis of marker-allele frequency changes in selection lines. TB analyses may be a useful alternative to MB analyses when interest is centered on a single quantitative trait only and costs of scoring for markers are high compared with costs of raising and obtaining quantitative trait information on F-2 or BC individuals. In this case, a TB analysis will enable equivalent power to be obtained with fewer individuals scored for the marker, but more individuals scored for the quantitative trait. MB analyses remain the method of choice when more than one quantitative trait is to be analyzed in a given population.
1432-2242
14322242
Springer
shingle_catch_all_3 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Summary Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in selection lines derived from the F-2 of a cross between inbred lines, or in the “high” and “low” phenotypic classes of an F-2 or BC population. The power of such trait-based (TB) analyses was evaluated and compared with that of methods for determining linkage based on the mean quantitative trait value of marker genotypes in F-2 or BC populations [marker-based (MB) analyses]. TB analyses can be utilized for marker-QTL linkage determination in situations where the MB analysis is not applicable, including analysis of polygenic resistance traits where only a part of the population survives exposure to the Stressor and analysis of marker-allele frequency changes in selection lines. TB analyses may be a useful alternative to MB analyses when interest is centered on a single quantitative trait only and costs of scoring for markers are high compared with costs of raising and obtaining quantitative trait information on F-2 or BC individuals. In this case, a TB analysis will enable equivalent power to be obtained with fewer individuals scored for the marker, but more individuals scored for the quantitative trait. MB analyses remain the method of choice when more than one quantitative trait is to be analyzed in a given population.
1432-2242
14322242
Springer
shingle_catch_all_4 Lebowitz, R. J.
Soller, M.
Beckmann, J. S.
Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Quantitative trait
Genetic markers
QTL
Linkage analysis
QTL mapping
Summary Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in selection lines derived from the F-2 of a cross between inbred lines, or in the “high” and “low” phenotypic classes of an F-2 or BC population. The power of such trait-based (TB) analyses was evaluated and compared with that of methods for determining linkage based on the mean quantitative trait value of marker genotypes in F-2 or BC populations [marker-based (MB) analyses]. TB analyses can be utilized for marker-QTL linkage determination in situations where the MB analysis is not applicable, including analysis of polygenic resistance traits where only a part of the population survives exposure to the Stressor and analysis of marker-allele frequency changes in selection lines. TB analyses may be a useful alternative to MB analyses when interest is centered on a single quantitative trait only and costs of scoring for markers are high compared with costs of raising and obtaining quantitative trait information on F-2 or BC individuals. In this case, a TB analysis will enable equivalent power to be obtained with fewer individuals scored for the marker, but more individuals scored for the quantitative trait. MB analyses remain the method of choice when more than one quantitative trait is to be analyzed in a given population.
1432-2242
14322242
Springer
shingle_title_1 Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
shingle_title_2 Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
shingle_title_3 Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
shingle_title_4 Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
sigel_instance_filter dkfz
geomar
wilbert
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albert
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:44:36.780Z
titel Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
titel_suche Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred lines
topic W
uid nat_lic_papers_NLM199844445