Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum

ISSN:
1432-1440
Keywords:
Diarrhoea ; Colostrum-acquired immunodeficiency syndrome ; Human immunodeficiency virus ; Cryptosporidiosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00184800
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autor Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
autorsonst Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
book_url http://dx.doi.org/10.1007/BF00184800
datenlieferant nat_lic_papers
hauptsatz hsatz_simple
identnr NLM199399247
issn 1432-1440
journal_name Journal of molecular medicine
materialart 1
notes Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.
package_name Springer
publikationsjahr_anzeige 1992
publikationsjahr_facette 1992
publikationsjahr_intervall 8009:1990-1994
publikationsjahr_sort 1992
publisher Springer
reference 70 (1992), S. 588-594
schlagwort Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
search_space articles
shingle_author_1 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
shingle_author_2 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
shingle_author_3 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
shingle_author_4 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
shingle_catch_all_1 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.
1432-1440
14321440
Springer
shingle_catch_all_2 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.
1432-1440
14321440
Springer
shingle_catch_all_3 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.
1432-1440
14321440
Springer
shingle_catch_all_4 Rump, J. A.
Arndt, R.
Arnold, A.
Bendick, C.
Dichtelmüller, H.
Franke, M.
Helm, E. B.
Jäger, H.
Kampmann, B.
Kolb, P.
Kreuz, W.
Lissner, R.
Meigel, W.
Ostendorf, P.
Peter, H. H.
Plettenberg, A.
Schedel, I.
Stellbrink, H. W.
Stephan, W.
Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Diarrhoea
Colostrum-acquired immunodeficiency syndrome
Human immunodeficiency virus
Cryptosporidiosis
Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.
1432-1440
14321440
Springer
shingle_title_1 Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
shingle_title_2 Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
shingle_title_3 Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
shingle_title_4 Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
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source_archive Springer Online Journal Archives 1860-2000
timestamp 2024-05-06T09:40:43.091Z
titel Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
titel_suche Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum
topic WW-YZ
uid nat_lic_papers_NLM199399247