Biopterin
| ISSN: |
1573-6903
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|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Repeated intraventricular injections of 2,4-diamino-6-hydroxypyrimidine (DAOPyr), inhibitor ofd-erythro-q-dihydroneopterin triphosphate synthetase, inhibited q-BH2 synthesis from GTP, markedly increased accumulation of 2-amino-4-hydroxy-5(or-6)-formamido-6-triphosphoribosylaminopyrimidine (FPyd-P3) and brought about a 60% decrease in the in vivo of reduced biopterin (BH2 and BH4) pool in the brain. Nevertheless, there was no effect on the rate of hydroxylation ofl-tryptophan or on the 5-hydroxytryptamine level in rat brain. These data emphasized the significance of the rate of hydrogen transfer and the limitation of the concept of “unsaturation” (i.e., the absolute amount of the carrier pterin molecule) for the synthesis of neurotransmitters in vivo.
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| Type of Medium: |
Electronic Resource
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| URL: |