Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption)
| ISSN: |
1573-2568
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|---|---|
| Keywords: |
LACTULOSE ; SUGAR MALABSORPTION ; WEIGHT GAIN ; COLITIS ; CELL PROLIFERATION ; APOPTOSIS
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract We sought to determine, in a piglet model,whether severe sugar malabsorption causes colonic injuryor inflammation. Twenty-four piglets were randomized toreceive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). Afterseven days, inflammation, apoptosis, and crypt cellproliferation were assessed in the proximal colon(cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2concentration was low, suggesting no increasedfermentation in the LAC group. Weight gain/volumeformula intake was identical in the CON and LAC groups(0.09 ± 0.13 and 0.09 ± 0.11 g/ml) respectively. Injury to thecolon did not occur, but inflammation of the colon(scale 0-5) was greater in LAC (score of 1.5 ±1.38) than in CON (0.42 ± 0.79; P 〈 0.05).Cell proliferation at the basal 40% of the crypt was 92% increasedin CON (labeling index 22.8 ± 9.9 vs 11.9± 2.8; P 〈 0.05). We conclude that persistentfeeding during severe sugar malabsorption permits weightgain but may cause colitis.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296642683666433 |
|---|---|
| autor | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario |
| autorsonst | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario |
| book_url | http://dx.doi.org/10.1023/A:1026672306929 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM197051502 |
| issn | 1573-2568 |
| journal_name | Digestive diseases and sciences |
| materialart | 1 |
| notes | Abstract We sought to determine, in a piglet model,whether severe sugar malabsorption causes colonic injuryor inflammation. Twenty-four piglets were randomized toreceive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). Afterseven days, inflammation, apoptosis, and crypt cellproliferation were assessed in the proximal colon(cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2concentration was low, suggesting no increasedfermentation in the LAC group. Weight gain/volumeformula intake was identical in the CON and LAC groups(0.09 ± 0.13 and 0.09 ± 0.11 g/ml) respectively. Injury to thecolon did not occur, but inflammation of the colon(scale 0-5) was greater in LAC (score of 1.5 ±1.38) than in CON (0.42 ± 0.79; P 〈 0.05).Cell proliferation at the basal 40% of the crypt was 92% increasedin CON (labeling index 22.8 ± 9.9 vs 11.9± 2.8; P 〈 0.05). We conclude that persistentfeeding during severe sugar malabsorption permits weightgain but may cause colitis. |
| package_name | Springer |
| publikationsjahr_anzeige | 1999 |
| publikationsjahr_facette | 1999 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1999 |
| publisher | Springer |
| reference | 44 (1999), S. 1476-1484 |
| schlagwort | LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS |
| search_space | articles |
| shingle_author_1 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario |
| shingle_author_2 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario |
| shingle_author_3 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario |
| shingle_author_4 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario |
| shingle_catch_all_1 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS Abstract We sought to determine, in a piglet model,whether severe sugar malabsorption causes colonic injuryor inflammation. Twenty-four piglets were randomized toreceive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). Afterseven days, inflammation, apoptosis, and crypt cellproliferation were assessed in the proximal colon(cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2concentration was low, suggesting no increasedfermentation in the LAC group. Weight gain/volumeformula intake was identical in the CON and LAC groups(0.09 ± 0.13 and 0.09 ± 0.11 g/ml) respectively. Injury to thecolon did not occur, but inflammation of the colon(scale 0-5) was greater in LAC (score of 1.5 ±1.38) than in CON (0.42 ± 0.79; P 〈 0.05).Cell proliferation at the basal 40% of the crypt was 92% increasedin CON (labeling index 22.8 ± 9.9 vs 11.9± 2.8; P 〈 0.05). We conclude that persistentfeeding during severe sugar malabsorption permits weightgain but may cause colitis. 1573-2568 15732568 Springer |
| shingle_catch_all_2 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS Abstract We sought to determine, in a piglet model,whether severe sugar malabsorption causes colonic injuryor inflammation. Twenty-four piglets were randomized toreceive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). Afterseven days, inflammation, apoptosis, and crypt cellproliferation were assessed in the proximal colon(cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2concentration was low, suggesting no increasedfermentation in the LAC group. Weight gain/volumeformula intake was identical in the CON and LAC groups(0.09 ± 0.13 and 0.09 ± 0.11 g/ml) respectively. Injury to thecolon did not occur, but inflammation of the colon(scale 0-5) was greater in LAC (score of 1.5 ±1.38) than in CON (0.42 ± 0.79; P 〈 0.05).Cell proliferation at the basal 40% of the crypt was 92% increasedin CON (labeling index 22.8 ± 9.9 vs 11.9± 2.8; P 〈 0.05). We conclude that persistentfeeding during severe sugar malabsorption permits weightgain but may cause colitis. 1573-2568 15732568 Springer |
| shingle_catch_all_3 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS Abstract We sought to determine, in a piglet model,whether severe sugar malabsorption causes colonic injuryor inflammation. Twenty-four piglets were randomized toreceive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). Afterseven days, inflammation, apoptosis, and crypt cellproliferation were assessed in the proximal colon(cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2concentration was low, suggesting no increasedfermentation in the LAC group. Weight gain/volumeformula intake was identical in the CON and LAC groups(0.09 ± 0.13 and 0.09 ± 0.11 g/ml) respectively. Injury to thecolon did not occur, but inflammation of the colon(scale 0-5) was greater in LAC (score of 1.5 ±1.38) than in CON (0.42 ± 0.79; P 〈 0.05).Cell proliferation at the basal 40% of the crypt was 92% increasedin CON (labeling index 22.8 ± 9.9 vs 11.9± 2.8; P 〈 0.05). We conclude that persistentfeeding during severe sugar malabsorption permits weightgain but may cause colitis. 1573-2568 15732568 Springer |
| shingle_catch_all_4 | Kien, C. Lawrence Murray, Robert D. Qualman, Stephen J. Marcon, Mario Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS LACTULOSE SUGAR MALABSORPTION WEIGHT GAIN COLITIS CELL PROLIFERATION APOPTOSIS Abstract We sought to determine, in a piglet model,whether severe sugar malabsorption causes colonic injuryor inflammation. Twenty-four piglets were randomized toreceive either control formula (CON) or CON supplemented with lactulose (LAC) (N = 12 each group). Afterseven days, inflammation, apoptosis, and crypt cellproliferation were assessed in the proximal colon(cecum). Lactulose feeding caused persistent diarrhea. In both groups, breath H2concentration was low, suggesting no increasedfermentation in the LAC group. Weight gain/volumeformula intake was identical in the CON and LAC groups(0.09 ± 0.13 and 0.09 ± 0.11 g/ml) respectively. Injury to thecolon did not occur, but inflammation of the colon(scale 0-5) was greater in LAC (score of 1.5 ±1.38) than in CON (0.42 ± 0.79; P 〈 0.05).Cell proliferation at the basal 40% of the crypt was 92% increasedin CON (labeling index 22.8 ± 9.9 vs 11.9± 2.8; P 〈 0.05). We conclude that persistentfeeding during severe sugar malabsorption permits weightgain but may cause colitis. 1573-2568 15732568 Springer |
| shingle_title_1 | Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) |
| shingle_title_2 | Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) |
| shingle_title_3 | Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) |
| shingle_title_4 | Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:21.318Z |
| titel | Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) |
| titel_suche | Lactulose Feeding in Piglets (A Model for Persistent Diarrhea and Colitis Induced by Severe Sugar Malabsorption) |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM197051502 |