Effect of a Dietary Nonionic Surfactant on Small Intestinal Nutrient Transport

1573-2568

JEJUNUM ; BIOLOGICAL TRANSPORT ; SURFACTANT ; GLUCOSE

Springer Online Journal Archives 1860-2000

Medicine

Abstract Nonionic surfactants are commonly present inmany prepared foods and drug formulations as stabilizingagents. The aim of the current study was to examine theeffect of the common nonionic surfactant Tween-80 on jejunal glucose transport. New Zealand Whiterabbits (800-1200 g) were fasted for 24 hr. Jejunaltissue was stripped and mounted in short-circuitedUssing chambers. Unidirectional 3-O-methyl glucose fluxes were determined during a 15-min basaltransport period and a subsequent 15-min experimentalperiod after the mucosal addition of Tween-80 at finalconcentrations of 0.001%, 0.01%, 0.05%, and 0.1%.Tween-80 at final concentrations of 0.1% and 0.05%significantly increased net 3-O-methyl glucose transportover basal levels. The increase in Jnet wasdue to a significant increase in the absorptive Jm-s flux. Tween-80 at 0.01% and0.001% did not significantly alter net glucose transportalthough Jm-s was significantly increased inthe presence of 0.01% Tween-80. Tween-80, inconcentrations commonly found in prepared foods, enhances theintestinal absorption of glucose.

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