Feasibility of low-dose and intermittent chenodeoxycholic acid therapy of gallstones
Marks, J. W. ; Bonorris, G. G. ; Chung, A. ; Coyne, M. J. ; Okun, R. ; Lachin, J. M. ; Schoenfield, L. J.
Springer
Published 1977
Springer
Published 1977
| ISSN: |
1573-2568
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Chenodeoxycholic acid, by reducing the concentration of biliary cholesterol relative to that of bile acid and phospholipid, dissolves cholesterol gallstones. This bile acid, however, has potential dose-related hepatotoxicity and causes dose-related diarrhea. Therefore, the feasibility of low-dose and intermittent therapy was assessed by studying the induction and persistence of chenodeoxycholic acid-induced biliary lipid changes. Biliary lipid composition with each of 3 doses of chenodeoxycholic acid was determined in bile samples obtained by cholecystokinin-stimulated duodenal drainage before, after one week and one month of treatment, and up to 9 weeks after discontinuation of treatment. The lowest dose that significantly reduced the relative concentration of biliary cholesterol was 250 mg/day. A significant reduction occurred one week after initiation of treatment and was maintained for 9 weeks follwing discontinuation of treatment. Thus, clinical trials of low-dose and intermittent chenodeoxycholic acid therapy for gallstone prophylaxis or dissolution are warranted.
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| Type of Medium: |
Electronic Resource
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| URL: |