Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods
Molino, A. ; Micciolo, R. ; Turazza, M. ; Bonetti, F. ; Piubello, Q. ; Corgnati, A. ; Sperotto, L. ; Martignoni, G. ; Bonetti, A. ; Nortilli, R. ; Castelli, P. ; Rodella, S. ; Capelli, P. ; Manfrin, E. ; Pelosi, G. ; Cetto, G. L.
Springer
Published 1995
Springer
Published 1995
| ISSN: |
1573-7217
|
|---|---|
| Keywords: |
biochemistry ; breast cancer ; estrogen receptors ; immunohistochemistry
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Summary Background: Over the last few years, estrogen receptor (ER) determination by immunohistochemistry (ER-ICA) has been extensively used, but it still remains to be established whether this method can replace the standard biochemical technique using dextran-coated charcoal (ERDCC). Patients and methods: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. The ‘best’ cut-off for ERICA was evaluated by means of Receiver Operating Characteristics (R.O.C.) analysis; logistic regression analysis was used to find adequate ‘weights’ for stain intensity. Results and conclusions: A significant correlation was found between the two methods (p 〈 0.001). R.O.C. analysis revealed that the ‘best’ cut-off for the ERICA score was 45% (sensitivity 0.810, specificity 0.804). Logistic regression analysis showed that an ERICA score which also considers staining intensity does not add any useful information concerning ER content in breast cancers.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296892347514880 |
|---|---|
| autor | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. |
| autorsonst | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. |
| book_url | http://dx.doi.org/10.1007/BF00689713 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM196734231 |
| issn | 1573-7217 |
| journal_name | Breast cancer research and treatment |
| materialart | 1 |
| notes | Summary Background: Over the last few years, estrogen receptor (ER) determination by immunohistochemistry (ER-ICA) has been extensively used, but it still remains to be established whether this method can replace the standard biochemical technique using dextran-coated charcoal (ERDCC). Patients and methods: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. The ‘best’ cut-off for ERICA was evaluated by means of Receiver Operating Characteristics (R.O.C.) analysis; logistic regression analysis was used to find adequate ‘weights’ for stain intensity. Results and conclusions: A significant correlation was found between the two methods (p 〈 0.001). R.O.C. analysis revealed that the ‘best’ cut-off for the ERICA score was 45% (sensitivity 0.810, specificity 0.804). Logistic regression analysis showed that an ERICA score which also considers staining intensity does not add any useful information concerning ER content in breast cancers. |
| package_name | Springer |
| publikationsjahr_anzeige | 1995 |
| publikationsjahr_facette | 1995 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1995 |
| publisher | Springer |
| reference | 34 (1995), S. 221-228 |
| schlagwort | biochemistry breast cancer estrogen receptors immunohistochemistry |
| search_space | articles |
| shingle_author_1 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. |
| shingle_author_2 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. |
| shingle_author_3 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. |
| shingle_author_4 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. |
| shingle_catch_all_1 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods biochemistry breast cancer estrogen receptors immunohistochemistry biochemistry breast cancer estrogen receptors immunohistochemistry Summary Background: Over the last few years, estrogen receptor (ER) determination by immunohistochemistry (ER-ICA) has been extensively used, but it still remains to be established whether this method can replace the standard biochemical technique using dextran-coated charcoal (ERDCC). Patients and methods: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. The ‘best’ cut-off for ERICA was evaluated by means of Receiver Operating Characteristics (R.O.C.) analysis; logistic regression analysis was used to find adequate ‘weights’ for stain intensity. Results and conclusions: A significant correlation was found between the two methods (p 〈 0.001). R.O.C. analysis revealed that the ‘best’ cut-off for the ERICA score was 45% (sensitivity 0.810, specificity 0.804). Logistic regression analysis showed that an ERICA score which also considers staining intensity does not add any useful information concerning ER content in breast cancers. 1573-7217 15737217 Springer |
| shingle_catch_all_2 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods biochemistry breast cancer estrogen receptors immunohistochemistry biochemistry breast cancer estrogen receptors immunohistochemistry Summary Background: Over the last few years, estrogen receptor (ER) determination by immunohistochemistry (ER-ICA) has been extensively used, but it still remains to be established whether this method can replace the standard biochemical technique using dextran-coated charcoal (ERDCC). Patients and methods: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. The ‘best’ cut-off for ERICA was evaluated by means of Receiver Operating Characteristics (R.O.C.) analysis; logistic regression analysis was used to find adequate ‘weights’ for stain intensity. Results and conclusions: A significant correlation was found between the two methods (p 〈 0.001). R.O.C. analysis revealed that the ‘best’ cut-off for the ERICA score was 45% (sensitivity 0.810, specificity 0.804). Logistic regression analysis showed that an ERICA score which also considers staining intensity does not add any useful information concerning ER content in breast cancers. 1573-7217 15737217 Springer |
| shingle_catch_all_3 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods biochemistry breast cancer estrogen receptors immunohistochemistry biochemistry breast cancer estrogen receptors immunohistochemistry Summary Background: Over the last few years, estrogen receptor (ER) determination by immunohistochemistry (ER-ICA) has been extensively used, but it still remains to be established whether this method can replace the standard biochemical technique using dextran-coated charcoal (ERDCC). Patients and methods: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. The ‘best’ cut-off for ERICA was evaluated by means of Receiver Operating Characteristics (R.O.C.) analysis; logistic regression analysis was used to find adequate ‘weights’ for stain intensity. Results and conclusions: A significant correlation was found between the two methods (p 〈 0.001). R.O.C. analysis revealed that the ‘best’ cut-off for the ERICA score was 45% (sensitivity 0.810, specificity 0.804). Logistic regression analysis showed that an ERICA score which also considers staining intensity does not add any useful information concerning ER content in breast cancers. 1573-7217 15737217 Springer |
| shingle_catch_all_4 | Molino, A. Micciolo, R. Turazza, M. Bonetti, F. Piubello, Q. Corgnati, A. Sperotto, L. Martignoni, G. Bonetti, A. Nortilli, R. Castelli, P. Rodella, S. Capelli, P. Manfrin, E. Pelosi, G. Cetto, G. L. Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods biochemistry breast cancer estrogen receptors immunohistochemistry biochemistry breast cancer estrogen receptors immunohistochemistry Summary Background: Over the last few years, estrogen receptor (ER) determination by immunohistochemistry (ER-ICA) has been extensively used, but it still remains to be established whether this method can replace the standard biochemical technique using dextran-coated charcoal (ERDCC). Patients and methods: ER were determined by both the dextran-coated charcoal (DCC) method and immunohistochemistry (ICA) in 699 patients with primary breast cancer; other parameters (age, pathological T-pT- and nodal status -pN-, progesterone receptors by DCC, proliferative index by ICA) were also recorded. The ‘best’ cut-off for ERICA was evaluated by means of Receiver Operating Characteristics (R.O.C.) analysis; logistic regression analysis was used to find adequate ‘weights’ for stain intensity. Results and conclusions: A significant correlation was found between the two methods (p 〈 0.001). R.O.C. analysis revealed that the ‘best’ cut-off for the ERICA score was 45% (sensitivity 0.810, specificity 0.804). Logistic regression analysis showed that an ERICA score which also considers staining intensity does not add any useful information concerning ER content in breast cancers. 1573-7217 15737217 Springer |
| shingle_title_1 | Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods |
| shingle_title_2 | Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods |
| shingle_title_3 | Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods |
| shingle_title_4 | Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:59:19.196Z |
| titel | Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods |
| titel_suche | Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM196734231 |