Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants
Flåøyen, A. ; Bratberg, B. ; Frøslie, A. ; Grønstøl, H. ; Langseth, W. ; Mantle, P.G. ; Von Krogh, A.
Springer
Published 1997
Springer
Published 1997
| ISSN: |
1573-7446
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|---|---|
| Keywords: |
calves ; creatinine ; enzymes ; kidney ; liver ; Narthecium ossifragum ; toxicity ; urea
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H., Langseth, W., Mantle, P.G. and Von Krogh, A., 1997. Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants. Veterinary Research Communications, 21 (2), 137-148 One calf was dosed during one day with an aqueous extract from 3.0 kg (wet weight) of Narthecium ossifragum and another was dosed on the same day with the insoluble plant residue. The concentrations of serum creatinine and magnesium increased only in the calf dosed with the aqueous extract, while the activity of glutamate dehydrogenase increased only in the serum of the calf dosed with the plant residue, so differentiating the nephrotoxic and hepatotoxic principles as water-soluble and water-insoluble compounds, respectively. One calf was dosed with 30 g (wet weight) N. ossifragum flower stems per kg live weight during one day and another was dosed with 30 g (wet weight) N. ossifragum leaves per kg live weight on the same day. The serum creatinine and urea concentrations and also the activities of glutamate dehydrogenase, aspartate aminotransferase and γ-glutamyltransferase in the serum increased in the calf dosed with the flower stems, whereas there was only a slight temporary increase in the creatinine concentration in serum from the calf dosed with the leaves. However, histopathological examination of the kidneys of the calf dosed with the flower stems revealed severe tubular necrosis and degeneration. It therefore appears that both the toxic principles are present in the flower stems of N. ossifragum rather than in its leaves. The serum creatinine concentration was significantly increased in a non-ruminating calf dosed with an aqueous extract from 32 g (wet weight) N. ossifragum per kg liveweight during one day, showing the intrinsic nephrotoxicity of the plant.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296923220738048 |
|---|---|
| autor | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. |
| autorsonst | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. |
| book_url | http://dx.doi.org/10.1023/A:1005781805723 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM196166543 |
| issn | 1573-7446 |
| journal_name | Veterinary research communications |
| materialart | 1 |
| notes | Abstract Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H., Langseth, W., Mantle, P.G. and Von Krogh, A., 1997. Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants. Veterinary Research Communications, 21 (2), 137-148 One calf was dosed during one day with an aqueous extract from 3.0 kg (wet weight) of Narthecium ossifragum and another was dosed on the same day with the insoluble plant residue. The concentrations of serum creatinine and magnesium increased only in the calf dosed with the aqueous extract, while the activity of glutamate dehydrogenase increased only in the serum of the calf dosed with the plant residue, so differentiating the nephrotoxic and hepatotoxic principles as water-soluble and water-insoluble compounds, respectively. One calf was dosed with 30 g (wet weight) N. ossifragum flower stems per kg live weight during one day and another was dosed with 30 g (wet weight) N. ossifragum leaves per kg live weight on the same day. The serum creatinine and urea concentrations and also the activities of glutamate dehydrogenase, aspartate aminotransferase and γ-glutamyltransferase in the serum increased in the calf dosed with the flower stems, whereas there was only a slight temporary increase in the creatinine concentration in serum from the calf dosed with the leaves. However, histopathological examination of the kidneys of the calf dosed with the flower stems revealed severe tubular necrosis and degeneration. It therefore appears that both the toxic principles are present in the flower stems of N. ossifragum rather than in its leaves. The serum creatinine concentration was significantly increased in a non-ruminating calf dosed with an aqueous extract from 32 g (wet weight) N. ossifragum per kg liveweight during one day, showing the intrinsic nephrotoxicity of the plant. |
| package_name | Springer |
| publikationsjahr_anzeige | 1997 |
| publikationsjahr_facette | 1997 |
| publikationsjahr_intervall | 8004:1995-1999 |
| publikationsjahr_sort | 1997 |
| publisher | Springer |
| reference | 21 (1997), S. 137-148 |
| schlagwort | calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea |
| search_space | articles |
| shingle_author_1 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. |
| shingle_author_2 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. |
| shingle_author_3 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. |
| shingle_author_4 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. |
| shingle_catch_all_1 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea Abstract Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H., Langseth, W., Mantle, P.G. and Von Krogh, A., 1997. Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants. Veterinary Research Communications, 21 (2), 137-148 One calf was dosed during one day with an aqueous extract from 3.0 kg (wet weight) of Narthecium ossifragum and another was dosed on the same day with the insoluble plant residue. The concentrations of serum creatinine and magnesium increased only in the calf dosed with the aqueous extract, while the activity of glutamate dehydrogenase increased only in the serum of the calf dosed with the plant residue, so differentiating the nephrotoxic and hepatotoxic principles as water-soluble and water-insoluble compounds, respectively. One calf was dosed with 30 g (wet weight) N. ossifragum flower stems per kg live weight during one day and another was dosed with 30 g (wet weight) N. ossifragum leaves per kg live weight on the same day. The serum creatinine and urea concentrations and also the activities of glutamate dehydrogenase, aspartate aminotransferase and γ-glutamyltransferase in the serum increased in the calf dosed with the flower stems, whereas there was only a slight temporary increase in the creatinine concentration in serum from the calf dosed with the leaves. However, histopathological examination of the kidneys of the calf dosed with the flower stems revealed severe tubular necrosis and degeneration. It therefore appears that both the toxic principles are present in the flower stems of N. ossifragum rather than in its leaves. The serum creatinine concentration was significantly increased in a non-ruminating calf dosed with an aqueous extract from 32 g (wet weight) N. ossifragum per kg liveweight during one day, showing the intrinsic nephrotoxicity of the plant. 1573-7446 15737446 Springer |
| shingle_catch_all_2 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea Abstract Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H., Langseth, W., Mantle, P.G. and Von Krogh, A., 1997. Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants. Veterinary Research Communications, 21 (2), 137-148 One calf was dosed during one day with an aqueous extract from 3.0 kg (wet weight) of Narthecium ossifragum and another was dosed on the same day with the insoluble plant residue. The concentrations of serum creatinine and magnesium increased only in the calf dosed with the aqueous extract, while the activity of glutamate dehydrogenase increased only in the serum of the calf dosed with the plant residue, so differentiating the nephrotoxic and hepatotoxic principles as water-soluble and water-insoluble compounds, respectively. One calf was dosed with 30 g (wet weight) N. ossifragum flower stems per kg live weight during one day and another was dosed with 30 g (wet weight) N. ossifragum leaves per kg live weight on the same day. The serum creatinine and urea concentrations and also the activities of glutamate dehydrogenase, aspartate aminotransferase and γ-glutamyltransferase in the serum increased in the calf dosed with the flower stems, whereas there was only a slight temporary increase in the creatinine concentration in serum from the calf dosed with the leaves. However, histopathological examination of the kidneys of the calf dosed with the flower stems revealed severe tubular necrosis and degeneration. It therefore appears that both the toxic principles are present in the flower stems of N. ossifragum rather than in its leaves. The serum creatinine concentration was significantly increased in a non-ruminating calf dosed with an aqueous extract from 32 g (wet weight) N. ossifragum per kg liveweight during one day, showing the intrinsic nephrotoxicity of the plant. 1573-7446 15737446 Springer |
| shingle_catch_all_3 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea Abstract Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H., Langseth, W., Mantle, P.G. and Von Krogh, A., 1997. Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants. Veterinary Research Communications, 21 (2), 137-148 One calf was dosed during one day with an aqueous extract from 3.0 kg (wet weight) of Narthecium ossifragum and another was dosed on the same day with the insoluble plant residue. The concentrations of serum creatinine and magnesium increased only in the calf dosed with the aqueous extract, while the activity of glutamate dehydrogenase increased only in the serum of the calf dosed with the plant residue, so differentiating the nephrotoxic and hepatotoxic principles as water-soluble and water-insoluble compounds, respectively. One calf was dosed with 30 g (wet weight) N. ossifragum flower stems per kg live weight during one day and another was dosed with 30 g (wet weight) N. ossifragum leaves per kg live weight on the same day. The serum creatinine and urea concentrations and also the activities of glutamate dehydrogenase, aspartate aminotransferase and γ-glutamyltransferase in the serum increased in the calf dosed with the flower stems, whereas there was only a slight temporary increase in the creatinine concentration in serum from the calf dosed with the leaves. However, histopathological examination of the kidneys of the calf dosed with the flower stems revealed severe tubular necrosis and degeneration. It therefore appears that both the toxic principles are present in the flower stems of N. ossifragum rather than in its leaves. The serum creatinine concentration was significantly increased in a non-ruminating calf dosed with an aqueous extract from 32 g (wet weight) N. ossifragum per kg liveweight during one day, showing the intrinsic nephrotoxicity of the plant. 1573-7446 15737446 Springer |
| shingle_catch_all_4 | Flåøyen, A. Bratberg, B. Frøslie, A. Grønstøl, H. Langseth, W. Mantle, P.G. Von Krogh, A. Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea calves creatinine enzymes kidney liver Narthecium ossifragum toxicity urea Abstract Flåøyen, A., Bratberg, B., Frøslie, A., Grønstøl, H., Langseth, W., Mantle, P.G. and Von Krogh, A., 1997. Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants. Veterinary Research Communications, 21 (2), 137-148 One calf was dosed during one day with an aqueous extract from 3.0 kg (wet weight) of Narthecium ossifragum and another was dosed on the same day with the insoluble plant residue. The concentrations of serum creatinine and magnesium increased only in the calf dosed with the aqueous extract, while the activity of glutamate dehydrogenase increased only in the serum of the calf dosed with the plant residue, so differentiating the nephrotoxic and hepatotoxic principles as water-soluble and water-insoluble compounds, respectively. One calf was dosed with 30 g (wet weight) N. ossifragum flower stems per kg live weight during one day and another was dosed with 30 g (wet weight) N. ossifragum leaves per kg live weight on the same day. The serum creatinine and urea concentrations and also the activities of glutamate dehydrogenase, aspartate aminotransferase and γ-glutamyltransferase in the serum increased in the calf dosed with the flower stems, whereas there was only a slight temporary increase in the creatinine concentration in serum from the calf dosed with the leaves. However, histopathological examination of the kidneys of the calf dosed with the flower stems revealed severe tubular necrosis and degeneration. It therefore appears that both the toxic principles are present in the flower stems of N. ossifragum rather than in its leaves. The serum creatinine concentration was significantly increased in a non-ruminating calf dosed with an aqueous extract from 32 g (wet weight) N. ossifragum per kg liveweight during one day, showing the intrinsic nephrotoxicity of the plant. 1573-7446 15737446 Springer |
| shingle_title_1 | Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants |
| shingle_title_2 | Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants |
| shingle_title_3 | Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants |
| shingle_title_4 | Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:59:48.008Z |
| titel | Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants |
| titel_suche | Further Studies on the Presence, Qualities and Effects of the Toxic Principles from Narthecium Ossifragum Plants |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM196166543 |