Role of the melanocortin-4 receptor in metabolic rate and food intake in mice
Chen, Airu S. ; Metzger, Joseph M. ; Trumbauer, Myrna E. ; Guan, Xiao-ming ; Yu, Hong ; Frazier, Easter G. ; Marsh, Donald J. ; Forrest, Michael J. ; Gopal-Truter, Shobhna ; Fisher, Jill ; Camacho, Ramon E. ; Strack, Alison M. ; Mellin, Theodore N. ; MacIntyre, D. Euan ; Chen, Howard Y. ; Ploeg, Lex H.T. Van der
Springer
Published 2000
Springer
Published 2000
| ISSN: |
1573-9368
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|---|---|
| Keywords: |
food intake ; melanocortin-4 receptor ; metabolic rate ; MT-II
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
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| Notes: |
Abstract We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.
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| Type of Medium: |
Electronic Resource
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| URL: |