Differentiation of Burkitt Lymphoma cells by Hexamethylenbisacetamide
Semmel, M. ; Hanania, N. ; Huet, S. ; Pavloff, N. ; Gay, F. ; Biquard, J. M.
Springer
Published 1988
Springer
Published 1988
| ISSN: |
1573-4978
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|---|---|
| Keywords: |
HMBA ; Burkitts Lymphoma ; c-myc ; tyrosine phosphorylation
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
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| Notes: |
Abstract Hexamethylenbisacetamide (HMBA) can induce the Burkitt lymphoma Raji cells to enter the differentiation process as evidenced by the decrease of HLA-DR antigens. This event is preceded by a decrease of c-myc expression and of the phosphorylation of cellular proteins, due toeither a decrease of tyrosine protein kinase activity or an increase of tyrosine phosphatase activity. These three events form a sequence and are part of the genetic program for differentiation and growth though they may not be causally related.
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| Type of Medium: |
Electronic Resource
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| URL: |