Quality control and statistical analysis of biodistribution of commercial99mTc-IDA derivatives
| ISSN: |
1588-2780
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
Energy, Environment Protection, Nuclear Power Engineering
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| Notes: |
Abstract The results obtained for radiochemical purity of ITLC (SA) and (SG) using different solvent systems and low voltage electrophoresis are presented in the paper. Radiochemical purities obtained for99mTc-dimethyl IDA (99mTc-HIDA) and99mTc-diethyl IDA (99mTc-EHIDA) are 98.1±0.6% and 98.7±0.5%, respectively. Variable99mTc hydrolyzate contents, depending on the ionic strength of the eluents and on the time interval between labelling and analysis, have been obtained by Sephadex chromatography. The eluent containing Sn-EHIDA inhibits dissociation of99mTc-EHIDA due to dilution of the preparation during elution of the column and yielding only a small percent of Sephadex bound fraction, as compared to other investigated eluents. The range of normal99mTc-IDA biodistribution values in the organs of experimental animals and statistical significance of the difference between these two preparations have also been determined. The results obtained for99mTc-HIDA and99mTc-EHIDA in the liver are 33.9±5% and 25.7±4.7%, respectively p〈0.01.
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| Type of Medium: |
Electronic Resource
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| URL: |