Effects of timolol on corneal sensitivity and tear production

1573-2630

beta-blocking agents ; corneal sensitivity ; tear production ; Schirmer test ; primary open-angle glaucoma

Springer Online Journal Archives 1860-2000

Medicine

Abstract A double-masked study was carried out to assess the effect of timolol ophthalmic solution on corneal sensitivity in seven normal volunteers. No significant change in corneal sensitivity was demonstrated during four weeks of timolol administration. Corneal sensitivity was determined in two age-matched groups, one comprising 27 glaucomatous patients on timolol therapy for at least three months and the other consisting of 24 normal individuals who had never been on any beta-blocking agents. No significant difference in corneal sensitivity was noted between the two groups. The tear production was determined by means of the Schirmer test I in 15 patients with primary open-angle glaucoma or ocular hypertension prior to and during timolol therapy of 13 months duration. No significant change in tear production was noted.

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