Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients
Castillo, Jose M. Benitez del ; Toledano, Nicolas ; Bañares, Antonio ; Hernandez, Cesar ; Arjona, Marcela ; Valle, David Díaz ; Sanchez, Julian Garcia
Springer
Published 1994
Springer
Published 1994
| ISSN: |
1573-2630
|
|---|---|
| Keywords: |
blood-aqueous barrier ; fluorophotometry ; acute anterior uveitis ; HLA B27
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P 〈 0.001) was found between the Kd of active HLA-B27 AAU (61.4±16.8×10−4 min−1) and the Kd of inactive HLA-B27 AAU (4.8±1.6×10−4 min−1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3±1.0×10−4min−1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism.
|
| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296653962149888 |
|---|---|
| autor | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia |
| autorsonst | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia |
| book_url | http://dx.doi.org/10.1007/BF00951804 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194445860 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P 〈 0.001) was found between the Kd of active HLA-B27 AAU (61.4±16.8×10−4 min−1) and the Kd of inactive HLA-B27 AAU (4.8±1.6×10−4 min−1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3±1.0×10−4min−1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism. |
| package_name | Springer |
| publikationsjahr_anzeige | 1994 |
| publikationsjahr_facette | 1994 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1994 |
| publisher | Springer |
| reference | 18 (1994), S. 233-236 |
| schlagwort | blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 |
| search_space | articles |
| shingle_author_1 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia |
| shingle_author_2 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia |
| shingle_author_3 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia |
| shingle_author_4 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia |
| shingle_catch_all_1 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 Abstract The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P 〈 0.001) was found between the Kd of active HLA-B27 AAU (61.4±16.8×10−4 min−1) and the Kd of inactive HLA-B27 AAU (4.8±1.6×10−4 min−1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3±1.0×10−4min−1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 Abstract The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P 〈 0.001) was found between the Kd of active HLA-B27 AAU (61.4±16.8×10−4 min−1) and the Kd of inactive HLA-B27 AAU (4.8±1.6×10−4 min−1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3±1.0×10−4min−1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 Abstract The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P 〈 0.001) was found between the Kd of active HLA-B27 AAU (61.4±16.8×10−4 min−1) and the Kd of inactive HLA-B27 AAU (4.8±1.6×10−4 min−1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3±1.0×10−4min−1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Castillo, Jose M. Benitez del Toledano, Nicolas Bañares, Antonio Hernandez, Cesar Arjona, Marcela Valle, David Díaz Sanchez, Julian Garcia Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 blood-aqueous barrier fluorophotometry acute anterior uveitis HLA B27 Abstract The blood-aqueous barrier (BAB) permeability was studied by fluorophotometry in 17 healthy control subjects and in 27 eyes from 27 patients with HLA-B27-positive acute anterior uveitis (HLA-B27 AAU). Twenty of these patients had an associated spondyloarthropathy. BAB permeability was studied during the ocular inflammatory crisis and in the disease-free periods in the same patients. Anterior chamber fluorophotometric scans were performed before and 30 minutes after the intravenous injection of 14 mg/kg of sodium fluorescein. The diffusion coefficient (Kd) was obtained from the ratio between the fluorescein concentration in the anterior chamber and the NPBF. Data were analyzed using the Student's t test and analysis of variance. A statistically significant difference (P 〈 0.001) was found between the Kd of active HLA-B27 AAU (61.4±16.8×10−4 min−1) and the Kd of inactive HLA-B27 AAU (4.8±1.6×10−4 min−1). No statistically significant differences were found between the Kd of inactive HLA-B27 AAU and the Kd of the control subjects (4.3±1.0×10−4min−1). We also failed to detect significant differences between patients with and without spondyloarthropathy either during the acute attack or during the disease-free period. On the basis of these results we conclude that the permeability of the BAB remains intact in inactive HLA-B27-positive AAU. The parallel fluorophotometric behaviour of HLA-B27-positive AAU with spondyloarthropathy and without spondyloarthropathy suggests that both share a common pathogenetic mechanism. 1573-2630 15732630 Springer |
| shingle_title_1 | Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients |
| shingle_title_2 | Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients |
| shingle_title_3 | Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients |
| shingle_title_4 | Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.938Z |
| titel | Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients |
| titel_suche | Blood-aqueous barrier permeability determination in HLA B27-positive acute anterior uveitis patients |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194445860 |