Biophysical characteristics of the Meibomian lipid layer underin vitro conditions
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
Meibomian gland secretion ; surface potential ; surface pressure
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The biophysical behaviour of the Meibomian gland secretion was tested underin vitro conditions. Thereby, simultaneous recording of surface pressure and surface potential was performed. The Meibomian lipid layer was compared with other surface-active components like polyvinylalcohol and polyvinylpyrrolidone. On the other hand, Eledoisin was tested as an example for a surface-inactive substance. An attempt was made to describe the biophysical interaction between a given artificial tear substitute and the Meibomian lipid layer. With respect to the surface potential Dipalmitoyl-phosphatidyl-choline was established as an analogue for Meibomian gland secretion. Fluorescence measurements in the presence of a cyanine dye (1 N,N′ dioctadecyloxacarbocyanine) were used as a method to localize the site of the characteristic potential change. From the fluorescence spectra under compression we conclude that the molecular change takes place at the lipid-subphase interface of the Meibomian lipid layer.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296653819543552 |
|---|---|
| autor | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger |
| autorsonst | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger |
| book_url | http://dx.doi.org/10.1007/BF00916437 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194444155 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract The biophysical behaviour of the Meibomian gland secretion was tested underin vitro conditions. Thereby, simultaneous recording of surface pressure and surface potential was performed. The Meibomian lipid layer was compared with other surface-active components like polyvinylalcohol and polyvinylpyrrolidone. On the other hand, Eledoisin was tested as an example for a surface-inactive substance. An attempt was made to describe the biophysical interaction between a given artificial tear substitute and the Meibomian lipid layer. With respect to the surface potential Dipalmitoyl-phosphatidyl-choline was established as an analogue for Meibomian gland secretion. Fluorescence measurements in the presence of a cyanine dye (1 N,N′ dioctadecyloxacarbocyanine) were used as a method to localize the site of the characteristic potential change. From the fluorescence spectra under compression we conclude that the molecular change takes place at the lipid-subphase interface of the Meibomian lipid layer. |
| package_name | Springer |
| publikationsjahr_anzeige | 1992 |
| publikationsjahr_facette | 1992 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1992 |
| publisher | Springer |
| reference | 16 (1992), S. 167-176 |
| schlagwort | Meibomian gland secretion surface potential surface pressure |
| search_space | articles |
| shingle_author_1 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger |
| shingle_author_2 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger |
| shingle_author_3 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger |
| shingle_author_4 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger |
| shingle_catch_all_1 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger Biophysical characteristics of the Meibomian lipid layer underin vitro conditions Meibomian gland secretion surface potential surface pressure Meibomian gland secretion surface potential surface pressure Abstract The biophysical behaviour of the Meibomian gland secretion was tested underin vitro conditions. Thereby, simultaneous recording of surface pressure and surface potential was performed. The Meibomian lipid layer was compared with other surface-active components like polyvinylalcohol and polyvinylpyrrolidone. On the other hand, Eledoisin was tested as an example for a surface-inactive substance. An attempt was made to describe the biophysical interaction between a given artificial tear substitute and the Meibomian lipid layer. With respect to the surface potential Dipalmitoyl-phosphatidyl-choline was established as an analogue for Meibomian gland secretion. Fluorescence measurements in the presence of a cyanine dye (1 N,N′ dioctadecyloxacarbocyanine) were used as a method to localize the site of the characteristic potential change. From the fluorescence spectra under compression we conclude that the molecular change takes place at the lipid-subphase interface of the Meibomian lipid layer. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger Biophysical characteristics of the Meibomian lipid layer underin vitro conditions Meibomian gland secretion surface potential surface pressure Meibomian gland secretion surface potential surface pressure Abstract The biophysical behaviour of the Meibomian gland secretion was tested underin vitro conditions. Thereby, simultaneous recording of surface pressure and surface potential was performed. The Meibomian lipid layer was compared with other surface-active components like polyvinylalcohol and polyvinylpyrrolidone. On the other hand, Eledoisin was tested as an example for a surface-inactive substance. An attempt was made to describe the biophysical interaction between a given artificial tear substitute and the Meibomian lipid layer. With respect to the surface potential Dipalmitoyl-phosphatidyl-choline was established as an analogue for Meibomian gland secretion. Fluorescence measurements in the presence of a cyanine dye (1 N,N′ dioctadecyloxacarbocyanine) were used as a method to localize the site of the characteristic potential change. From the fluorescence spectra under compression we conclude that the molecular change takes place at the lipid-subphase interface of the Meibomian lipid layer. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger Biophysical characteristics of the Meibomian lipid layer underin vitro conditions Meibomian gland secretion surface potential surface pressure Meibomian gland secretion surface potential surface pressure Abstract The biophysical behaviour of the Meibomian gland secretion was tested underin vitro conditions. Thereby, simultaneous recording of surface pressure and surface potential was performed. The Meibomian lipid layer was compared with other surface-active components like polyvinylalcohol and polyvinylpyrrolidone. On the other hand, Eledoisin was tested as an example for a surface-inactive substance. An attempt was made to describe the biophysical interaction between a given artificial tear substitute and the Meibomian lipid layer. With respect to the surface potential Dipalmitoyl-phosphatidyl-choline was established as an analogue for Meibomian gland secretion. Fluorescence measurements in the presence of a cyanine dye (1 N,N′ dioctadecyloxacarbocyanine) were used as a method to localize the site of the characteristic potential change. From the fluorescence spectra under compression we conclude that the molecular change takes place at the lipid-subphase interface of the Meibomian lipid layer. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Kaercher, Thomas Möbius, Dietmar Welt, Rüdiger Biophysical characteristics of the Meibomian lipid layer underin vitro conditions Meibomian gland secretion surface potential surface pressure Meibomian gland secretion surface potential surface pressure Abstract The biophysical behaviour of the Meibomian gland secretion was tested underin vitro conditions. Thereby, simultaneous recording of surface pressure and surface potential was performed. The Meibomian lipid layer was compared with other surface-active components like polyvinylalcohol and polyvinylpyrrolidone. On the other hand, Eledoisin was tested as an example for a surface-inactive substance. An attempt was made to describe the biophysical interaction between a given artificial tear substitute and the Meibomian lipid layer. With respect to the surface potential Dipalmitoyl-phosphatidyl-choline was established as an analogue for Meibomian gland secretion. Fluorescence measurements in the presence of a cyanine dye (1 N,N′ dioctadecyloxacarbocyanine) were used as a method to localize the site of the characteristic potential change. From the fluorescence spectra under compression we conclude that the molecular change takes place at the lipid-subphase interface of the Meibomian lipid layer. 1573-2630 15732630 Springer |
| shingle_title_1 | Biophysical characteristics of the Meibomian lipid layer underin vitro conditions |
| shingle_title_2 | Biophysical characteristics of the Meibomian lipid layer underin vitro conditions |
| shingle_title_3 | Biophysical characteristics of the Meibomian lipid layer underin vitro conditions |
| shingle_title_4 | Biophysical characteristics of the Meibomian lipid layer underin vitro conditions |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.938Z |
| titel | Biophysical characteristics of the Meibomian lipid layer underin vitro conditions |
| titel_suche | Biophysical characteristics of the Meibomian lipid layer underin vitro conditions |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194444155 |