Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
Ara-C ; 5-FU ; microsphere encapsulation ; PVR ; lactic and glycolic acid
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Experiments were conducted with biodegradable microspheres containing antimetabolites to assess the release of the drugs from the microspheres into the vitreous cavity of primates. Microspheres containing a mixture of radiolabeled and cold cytosine arabinoside (Ara-C) or 5-fluorouracil (5-FU) were prepared using a solvent evaporation process. The copolymers of poly (lactic) and poly (glycolic) acid (85∶15) and drug was dissolved in a mixture of chloroform and acetone. The solutions were then emulsified in an aqueous solution of polyvinyl alcohol and stirred for 24 hours to evaporate the organic solvent. A 0.1 mL aliquot of a suspension of the microspheres was then injected into one eye of eight African Green monkeys. Half received 250±10μg of Ara-C and the others 375±15μg of 5-FU. The concentration in the vitreous was then measured by removing a 0.1 mL sample of vitreous at 1, 2, 4 and 11 days after injection. Both drugs released from microspheres were still detectable in the eye 11 days after injection and the clearance kinetics were similar for both drugs. The results indicate that the microspheres appear promising as a slow drugdelivery system for future investigations in conjunction with these and other antimetabolites suitable for the treatment of PVR.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296653809057793 |
|---|---|
| autor | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth |
| autorsonst | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth |
| book_url | http://dx.doi.org/10.1007/BF00918942 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194444023 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract Experiments were conducted with biodegradable microspheres containing antimetabolites to assess the release of the drugs from the microspheres into the vitreous cavity of primates. Microspheres containing a mixture of radiolabeled and cold cytosine arabinoside (Ara-C) or 5-fluorouracil (5-FU) were prepared using a solvent evaporation process. The copolymers of poly (lactic) and poly (glycolic) acid (85∶15) and drug was dissolved in a mixture of chloroform and acetone. The solutions were then emulsified in an aqueous solution of polyvinyl alcohol and stirred for 24 hours to evaporate the organic solvent. A 0.1 mL aliquot of a suspension of the microspheres was then injected into one eye of eight African Green monkeys. Half received 250±10μg of Ara-C and the others 375±15μg of 5-FU. The concentration in the vitreous was then measured by removing a 0.1 mL sample of vitreous at 1, 2, 4 and 11 days after injection. Both drugs released from microspheres were still detectable in the eye 11 days after injection and the clearance kinetics were similar for both drugs. The results indicate that the microspheres appear promising as a slow drugdelivery system for future investigations in conjunction with these and other antimetabolites suitable for the treatment of PVR. |
| package_name | Springer |
| publikationsjahr_anzeige | 1992 |
| publikationsjahr_facette | 1992 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1992 |
| publisher | Springer |
| reference | 16 (1992), S. 109-113 |
| schlagwort | Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid |
| search_space | articles |
| shingle_author_1 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth |
| shingle_author_2 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth |
| shingle_author_3 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth |
| shingle_author_4 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth |
| shingle_catch_all_1 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Abstract Experiments were conducted with biodegradable microspheres containing antimetabolites to assess the release of the drugs from the microspheres into the vitreous cavity of primates. Microspheres containing a mixture of radiolabeled and cold cytosine arabinoside (Ara-C) or 5-fluorouracil (5-FU) were prepared using a solvent evaporation process. The copolymers of poly (lactic) and poly (glycolic) acid (85∶15) and drug was dissolved in a mixture of chloroform and acetone. The solutions were then emulsified in an aqueous solution of polyvinyl alcohol and stirred for 24 hours to evaporate the organic solvent. A 0.1 mL aliquot of a suspension of the microspheres was then injected into one eye of eight African Green monkeys. Half received 250±10μg of Ara-C and the others 375±15μg of 5-FU. The concentration in the vitreous was then measured by removing a 0.1 mL sample of vitreous at 1, 2, 4 and 11 days after injection. Both drugs released from microspheres were still detectable in the eye 11 days after injection and the clearance kinetics were similar for both drugs. The results indicate that the microspheres appear promising as a slow drugdelivery system for future investigations in conjunction with these and other antimetabolites suitable for the treatment of PVR. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Abstract Experiments were conducted with biodegradable microspheres containing antimetabolites to assess the release of the drugs from the microspheres into the vitreous cavity of primates. Microspheres containing a mixture of radiolabeled and cold cytosine arabinoside (Ara-C) or 5-fluorouracil (5-FU) were prepared using a solvent evaporation process. The copolymers of poly (lactic) and poly (glycolic) acid (85∶15) and drug was dissolved in a mixture of chloroform and acetone. The solutions were then emulsified in an aqueous solution of polyvinyl alcohol and stirred for 24 hours to evaporate the organic solvent. A 0.1 mL aliquot of a suspension of the microspheres was then injected into one eye of eight African Green monkeys. Half received 250±10μg of Ara-C and the others 375±15μg of 5-FU. The concentration in the vitreous was then measured by removing a 0.1 mL sample of vitreous at 1, 2, 4 and 11 days after injection. Both drugs released from microspheres were still detectable in the eye 11 days after injection and the clearance kinetics were similar for both drugs. The results indicate that the microspheres appear promising as a slow drugdelivery system for future investigations in conjunction with these and other antimetabolites suitable for the treatment of PVR. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Abstract Experiments were conducted with biodegradable microspheres containing antimetabolites to assess the release of the drugs from the microspheres into the vitreous cavity of primates. Microspheres containing a mixture of radiolabeled and cold cytosine arabinoside (Ara-C) or 5-fluorouracil (5-FU) were prepared using a solvent evaporation process. The copolymers of poly (lactic) and poly (glycolic) acid (85∶15) and drug was dissolved in a mixture of chloroform and acetone. The solutions were then emulsified in an aqueous solution of polyvinyl alcohol and stirred for 24 hours to evaporate the organic solvent. A 0.1 mL aliquot of a suspension of the microspheres was then injected into one eye of eight African Green monkeys. Half received 250±10μg of Ara-C and the others 375±15μg of 5-FU. The concentration in the vitreous was then measured by removing a 0.1 mL sample of vitreous at 1, 2, 4 and 11 days after injection. Both drugs released from microspheres were still detectable in the eye 11 days after injection and the clearance kinetics were similar for both drugs. The results indicate that the microspheres appear promising as a slow drugdelivery system for future investigations in conjunction with these and other antimetabolites suitable for the treatment of PVR. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Peyman, Gholam A. Conway, Mandi Khoobehi, Bahram Soike, Kenneth Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Ara-C 5-FU microsphere encapsulation PVR lactic and glycolic acid Abstract Experiments were conducted with biodegradable microspheres containing antimetabolites to assess the release of the drugs from the microspheres into the vitreous cavity of primates. Microspheres containing a mixture of radiolabeled and cold cytosine arabinoside (Ara-C) or 5-fluorouracil (5-FU) were prepared using a solvent evaporation process. The copolymers of poly (lactic) and poly (glycolic) acid (85∶15) and drug was dissolved in a mixture of chloroform and acetone. The solutions were then emulsified in an aqueous solution of polyvinyl alcohol and stirred for 24 hours to evaporate the organic solvent. A 0.1 mL aliquot of a suspension of the microspheres was then injected into one eye of eight African Green monkeys. Half received 250±10μg of Ara-C and the others 375±15μg of 5-FU. The concentration in the vitreous was then measured by removing a 0.1 mL sample of vitreous at 1, 2, 4 and 11 days after injection. Both drugs released from microspheres were still detectable in the eye 11 days after injection and the clearance kinetics were similar for both drugs. The results indicate that the microspheres appear promising as a slow drugdelivery system for future investigations in conjunction with these and other antimetabolites suitable for the treatment of PVR. 1573-2630 15732630 Springer |
| shingle_title_1 | Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates |
| shingle_title_2 | Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates |
| shingle_title_3 | Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates |
| shingle_title_4 | Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.938Z |
| titel | Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates |
| titel_suche | Clearance of microsphere-entrapped 5-fluorouracil and cytosine arabinoside from the vitreous of primates |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194444023 |