Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats
Bahgat, Mostafa ; Anis, Hossam H. ; Peyman, Gholam A. ; Farahat, Hassan G. ; Parry, Gareth J. ; Khoobehi, Bahram
Springer
Published 1991
Springer
Published 1991
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
piroxicam ; streptozocin ; blood-retina barrier ; vitreous fluorophotometry ; platelet aggregation
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296653770260482 |
|---|---|
| autor | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram |
| autorsonst | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram |
| book_url | http://dx.doi.org/10.1007/BF00128953 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194443655 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification. |
| package_name | Springer |
| publikationsjahr_anzeige | 1991 |
| publikationsjahr_facette | 1991 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1991 |
| publisher | Springer |
| reference | 15 (1991), S. 335-341 |
| schlagwort | piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation |
| search_space | articles |
| shingle_author_1 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram |
| shingle_author_2 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram |
| shingle_author_3 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram |
| shingle_author_4 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram |
| shingle_catch_all_1 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation Abstract The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation Abstract The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation Abstract The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Bahgat, Mostafa Anis, Hossam H. Peyman, Gholam A. Farahat, Hassan G. Parry, Gareth J. Khoobehi, Bahram Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation piroxicam streptozocin blood-retina barrier vitreous fluorophotometry platelet aggregation Abstract The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification. 1573-2630 15732630 Springer |
| shingle_title_1 | Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats |
| shingle_title_2 | Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats |
| shingle_title_3 | Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats |
| shingle_title_4 | Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.938Z |
| titel | Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats |
| titel_suche | Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194443655 |