Chemoattractants produced by ocular cells induce trabecular meshwork cell migration

Calthorpe, C. M. ; Grierson, I. ; Hitchings, R. A.
Springer
Published 1991
ISSN:
1573-2630
Keywords:
Trabecular meshwork cells ; migration ; conditioned medium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Media conditioned by bovine corneal endothelium and scleral fibroblasts were found to induce the migration of bovine trabecular meshwork cells. The migrational activity had both chemokinetic (stimulated random motion) and chemotactic (directional migration) components. That produced by corneal endothelial cells had a markedly more potent effect. The relevance of these in vitro studies is discussed. Biochemically stimulated migration and loss of meshwork cells may be involved in the pathogenesis of glaucoma.
Type of Medium:
Electronic Resource
URL: