Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
immunoglobulins ; secretory-IgA ; Sjögren syndrome ; tears
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The objective of the present study was to examine Secretory IgA in tears and serum of Sjögren patients (34 patients and 23 controls). The test was performed in a parallel study using a polyclonal and a monoclonal method (Inter-Assay variation 9.1/Intra-Assay variation 5.5). No differences in the levels of tear secretory IgA were found between patients and controls. In serum however, secretory IgA, total IgA, IgM and IgG showed a significant increase in the Sjögren patients. The fact that secretory IgA levels remain normal in the ocular mucosa of these patients may explain that, despite the autoimmune destruction of the lacrimal gland, humoral defense factors are normally present on the surface of the eye to combat infections.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296653736706049 |
|---|---|
| autor | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. |
| autorsonst | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. |
| book_url | http://dx.doi.org/10.1007/BF00153916 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194443280 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract The objective of the present study was to examine Secretory IgA in tears and serum of Sjögren patients (34 patients and 23 controls). The test was performed in a parallel study using a polyclonal and a monoclonal method (Inter-Assay variation 9.1/Intra-Assay variation 5.5). No differences in the levels of tear secretory IgA were found between patients and controls. In serum however, secretory IgA, total IgA, IgM and IgG showed a significant increase in the Sjögren patients. The fact that secretory IgA levels remain normal in the ocular mucosa of these patients may explain that, despite the autoimmune destruction of the lacrimal gland, humoral defense factors are normally present on the surface of the eye to combat infections. |
| package_name | Springer |
| publikationsjahr_anzeige | 1991 |
| publikationsjahr_facette | 1991 |
| publikationsjahr_intervall | 8009:1990-1994 |
| publikationsjahr_sort | 1991 |
| publisher | Springer |
| reference | 15 (1991), S. 147-151 |
| schlagwort | immunoglobulins secretory-IgA Sjögren syndrome tears |
| search_space | articles |
| shingle_author_1 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. |
| shingle_author_2 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. |
| shingle_author_3 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. |
| shingle_author_4 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. |
| shingle_catch_all_1 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA immunoglobulins secretory-IgA Sjögren syndrome tears immunoglobulins secretory-IgA Sjögren syndrome tears Abstract The objective of the present study was to examine Secretory IgA in tears and serum of Sjögren patients (34 patients and 23 controls). The test was performed in a parallel study using a polyclonal and a monoclonal method (Inter-Assay variation 9.1/Intra-Assay variation 5.5). No differences in the levels of tear secretory IgA were found between patients and controls. In serum however, secretory IgA, total IgA, IgM and IgG showed a significant increase in the Sjögren patients. The fact that secretory IgA levels remain normal in the ocular mucosa of these patients may explain that, despite the autoimmune destruction of the lacrimal gland, humoral defense factors are normally present on the surface of the eye to combat infections. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA immunoglobulins secretory-IgA Sjögren syndrome tears immunoglobulins secretory-IgA Sjögren syndrome tears Abstract The objective of the present study was to examine Secretory IgA in tears and serum of Sjögren patients (34 patients and 23 controls). The test was performed in a parallel study using a polyclonal and a monoclonal method (Inter-Assay variation 9.1/Intra-Assay variation 5.5). No differences in the levels of tear secretory IgA were found between patients and controls. In serum however, secretory IgA, total IgA, IgM and IgG showed a significant increase in the Sjögren patients. The fact that secretory IgA levels remain normal in the ocular mucosa of these patients may explain that, despite the autoimmune destruction of the lacrimal gland, humoral defense factors are normally present on the surface of the eye to combat infections. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA immunoglobulins secretory-IgA Sjögren syndrome tears immunoglobulins secretory-IgA Sjögren syndrome tears Abstract The objective of the present study was to examine Secretory IgA in tears and serum of Sjögren patients (34 patients and 23 controls). The test was performed in a parallel study using a polyclonal and a monoclonal method (Inter-Assay variation 9.1/Intra-Assay variation 5.5). No differences in the levels of tear secretory IgA were found between patients and controls. In serum however, secretory IgA, total IgA, IgM and IgG showed a significant increase in the Sjögren patients. The fact that secretory IgA levels remain normal in the ocular mucosa of these patients may explain that, despite the autoimmune destruction of the lacrimal gland, humoral defense factors are normally present on the surface of the eye to combat infections. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Wehmeyer, A. Das, P. K. Swaak, T. Gebhart, W. Kijlstra, A. Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA immunoglobulins secretory-IgA Sjögren syndrome tears immunoglobulins secretory-IgA Sjögren syndrome tears Abstract The objective of the present study was to examine Secretory IgA in tears and serum of Sjögren patients (34 patients and 23 controls). The test was performed in a parallel study using a polyclonal and a monoclonal method (Inter-Assay variation 9.1/Intra-Assay variation 5.5). No differences in the levels of tear secretory IgA were found between patients and controls. In serum however, secretory IgA, total IgA, IgM and IgG showed a significant increase in the Sjögren patients. The fact that secretory IgA levels remain normal in the ocular mucosa of these patients may explain that, despite the autoimmune destruction of the lacrimal gland, humoral defense factors are normally present on the surface of the eye to combat infections. 1573-2630 15732630 Springer |
| shingle_title_1 | Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA |
| shingle_title_2 | Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA |
| shingle_title_3 | Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA |
| shingle_title_4 | Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.938Z |
| titel | Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA |
| titel_suche | Sjögren syndrome: comparative studies in local ocular and serum immunoglobulin concentrations with special reference to secretory IgA |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194443280 |