Evaluation of daunomycin toxicity on lens epithelium in vitro
Weller, Michael ; Wiedemann, Peter ; Fischbach, Roman ; Hartmann, Christian ; Heimann, Klaus
Springer
Published 1988
Springer
Published 1988
| ISSN: |
1573-2630
|
|---|---|
| Keywords: |
lens epithelium ; extracapsular cataract extraction ; posterior capsule opacification ; daunomycin
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| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Medicine
|
| Notes: |
Abstract Posterior capsule opacification is the major complication of extracapsular cataract extraction (ECCE). Lens epithelial cells derived from the periphery of the lens are thought to migrate posteriorly and contribute significantly to the postoperative proliferations at the posterior pole. We have evaluated the effects of the antiproliferative drug daunomycin on cultured porcine lens epithelial cell viability and proliferation. We observed that the mitotic activity of the cells is suppressed by a single short time treatment with daunomycin at a concentration as low as 2.5 mg/l. Long term effects on the reproductive capacity of the lens epithelial cells may not be as pronounced as the inhibition of other cells examined before e.g. retinal pigment epithelium and fibroblasts. Our results indicate that daunomycin may be useful for the pharmacologic prevention of postoperative proliferations in patients treated by ECCE.
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| Type of Medium: |
Electronic Resource
|
| URL: |
| _version_ | 1798296654114193409 |
|---|---|
| autor | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus |
| autorsonst | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus |
| book_url | http://dx.doi.org/10.1007/BF00137138 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194441121 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract Posterior capsule opacification is the major complication of extracapsular cataract extraction (ECCE). Lens epithelial cells derived from the periphery of the lens are thought to migrate posteriorly and contribute significantly to the postoperative proliferations at the posterior pole. We have evaluated the effects of the antiproliferative drug daunomycin on cultured porcine lens epithelial cell viability and proliferation. We observed that the mitotic activity of the cells is suppressed by a single short time treatment with daunomycin at a concentration as low as 2.5 mg/l. Long term effects on the reproductive capacity of the lens epithelial cells may not be as pronounced as the inhibition of other cells examined before e.g. retinal pigment epithelium and fibroblasts. Our results indicate that daunomycin may be useful for the pharmacologic prevention of postoperative proliferations in patients treated by ECCE. |
| package_name | Springer |
| publikationsjahr_anzeige | 1988 |
| publikationsjahr_facette | 1988 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1988 |
| publisher | Springer |
| reference | 12 (1988), S. 127-130 |
| schlagwort | lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin |
| search_space | articles |
| shingle_author_1 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus |
| shingle_author_2 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus |
| shingle_author_3 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus |
| shingle_author_4 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus |
| shingle_catch_all_1 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus Evaluation of daunomycin toxicity on lens epithelium in vitro lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin Abstract Posterior capsule opacification is the major complication of extracapsular cataract extraction (ECCE). Lens epithelial cells derived from the periphery of the lens are thought to migrate posteriorly and contribute significantly to the postoperative proliferations at the posterior pole. We have evaluated the effects of the antiproliferative drug daunomycin on cultured porcine lens epithelial cell viability and proliferation. We observed that the mitotic activity of the cells is suppressed by a single short time treatment with daunomycin at a concentration as low as 2.5 mg/l. Long term effects on the reproductive capacity of the lens epithelial cells may not be as pronounced as the inhibition of other cells examined before e.g. retinal pigment epithelium and fibroblasts. Our results indicate that daunomycin may be useful for the pharmacologic prevention of postoperative proliferations in patients treated by ECCE. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus Evaluation of daunomycin toxicity on lens epithelium in vitro lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin Abstract Posterior capsule opacification is the major complication of extracapsular cataract extraction (ECCE). Lens epithelial cells derived from the periphery of the lens are thought to migrate posteriorly and contribute significantly to the postoperative proliferations at the posterior pole. We have evaluated the effects of the antiproliferative drug daunomycin on cultured porcine lens epithelial cell viability and proliferation. We observed that the mitotic activity of the cells is suppressed by a single short time treatment with daunomycin at a concentration as low as 2.5 mg/l. Long term effects on the reproductive capacity of the lens epithelial cells may not be as pronounced as the inhibition of other cells examined before e.g. retinal pigment epithelium and fibroblasts. Our results indicate that daunomycin may be useful for the pharmacologic prevention of postoperative proliferations in patients treated by ECCE. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus Evaluation of daunomycin toxicity on lens epithelium in vitro lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin Abstract Posterior capsule opacification is the major complication of extracapsular cataract extraction (ECCE). Lens epithelial cells derived from the periphery of the lens are thought to migrate posteriorly and contribute significantly to the postoperative proliferations at the posterior pole. We have evaluated the effects of the antiproliferative drug daunomycin on cultured porcine lens epithelial cell viability and proliferation. We observed that the mitotic activity of the cells is suppressed by a single short time treatment with daunomycin at a concentration as low as 2.5 mg/l. Long term effects on the reproductive capacity of the lens epithelial cells may not be as pronounced as the inhibition of other cells examined before e.g. retinal pigment epithelium and fibroblasts. Our results indicate that daunomycin may be useful for the pharmacologic prevention of postoperative proliferations in patients treated by ECCE. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Weller, Michael Wiedemann, Peter Fischbach, Roman Hartmann, Christian Heimann, Klaus Evaluation of daunomycin toxicity on lens epithelium in vitro lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin lens epithelium extracapsular cataract extraction posterior capsule opacification daunomycin Abstract Posterior capsule opacification is the major complication of extracapsular cataract extraction (ECCE). Lens epithelial cells derived from the periphery of the lens are thought to migrate posteriorly and contribute significantly to the postoperative proliferations at the posterior pole. We have evaluated the effects of the antiproliferative drug daunomycin on cultured porcine lens epithelial cell viability and proliferation. We observed that the mitotic activity of the cells is suppressed by a single short time treatment with daunomycin at a concentration as low as 2.5 mg/l. Long term effects on the reproductive capacity of the lens epithelial cells may not be as pronounced as the inhibition of other cells examined before e.g. retinal pigment epithelium and fibroblasts. Our results indicate that daunomycin may be useful for the pharmacologic prevention of postoperative proliferations in patients treated by ECCE. 1573-2630 15732630 Springer |
| shingle_title_1 | Evaluation of daunomycin toxicity on lens epithelium in vitro |
| shingle_title_2 | Evaluation of daunomycin toxicity on lens epithelium in vitro |
| shingle_title_3 | Evaluation of daunomycin toxicity on lens epithelium in vitro |
| shingle_title_4 | Evaluation of daunomycin toxicity on lens epithelium in vitro |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.733Z |
| titel | Evaluation of daunomycin toxicity on lens epithelium in vitro |
| titel_suche | Evaluation of daunomycin toxicity on lens epithelium in vitro |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194441121 |