Conjunctival lymphocyte subsets in trachoma
| ISSN: |
1573-2630
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|---|---|
| Keywords: |
B-lymphocytes ; T-lymphocytes ; conjunctiva ; cytotoxic/suppressor lymphocytes ; helper/inducer ; lymphocytes ; monoclonal antibodies ; Chlamydia trachomatis ; trachoma
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/ cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296654091124737 |
|---|---|
| autor | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. |
| autorsonst | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. |
| book_url | http://dx.doi.org/10.1007/BF00133782 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194440990 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/ cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM. |
| package_name | Springer |
| publikationsjahr_anzeige | 1988 |
| publikationsjahr_facette | 1988 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1988 |
| publisher | Springer |
| reference | 12 (1988), S. 53-57 |
| schlagwort | B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma |
| search_space | articles |
| shingle_author_1 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. |
| shingle_author_2 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. |
| shingle_author_3 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. |
| shingle_author_4 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. |
| shingle_catch_all_1 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. Conjunctival lymphocyte subsets in trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma Abstract Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/ cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. Conjunctival lymphocyte subsets in trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma Abstract Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/ cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. Conjunctival lymphocyte subsets in trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma Abstract Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/ cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Burd, Eileen M. Tabbara, Khalid F. Nasr, Amin M. Taylor, Peter B. Conjunctival lymphocyte subsets in trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma B-lymphocytes T-lymphocytes conjunctiva cytotoxic/suppressor lymphocytes helper/inducer lymphocytes lymphocytes monoclonal antibodies Chlamydia trachomatis trachoma Abstract Monoclonal antibodies were used to assess the lymphocyte populations in conjunctival biopsy specimens obtained from patients with trachoma (active or inactive) undergoing tarsotomy for the correction of trachoma-induced entropion and in three control patients. Peroxidase-labelled monoclonal antibodies OKT4 (identifies T-helper/inducer lymphocytes), OKT8 (identifies T-suppressor/cytotoxic lymphocytes), OKIal (identifies B-lymphocytes) and antisera specific for IgG, IgA and IgM were used to identify lymphocyte subpopulations and immunoglobulins in the conjunctival biopsy specimens. When grouped by disease activity, conjunctival tissue specimens revealed predominant T-helper/inducer lymphocytes in the substantia propria of patients with active trachoma while inactive trachoma patients had predominant T-suppressor/ cytotoxic lymphocytes in the conjunctival biopsy specimens. B-lymphocytes were seen in moderate numbers in all conjunctival biopsy specimens from patients with active trachoma and all specimens from active cases stained for IgG, IgM, and IgA. Immunoglobulin staining was strongest with IgG and IgM. 1573-2630 15732630 Springer |
| shingle_title_1 | Conjunctival lymphocyte subsets in trachoma |
| shingle_title_2 | Conjunctival lymphocyte subsets in trachoma |
| shingle_title_3 | Conjunctival lymphocyte subsets in trachoma |
| shingle_title_4 | Conjunctival lymphocyte subsets in trachoma |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.733Z |
| titel | Conjunctival lymphocyte subsets in trachoma |
| titel_suche | Conjunctival lymphocyte subsets in trachoma |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194440990 |