Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy
| ISSN: |
1573-2630
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| Keywords: |
proliferative vitreoretinopathy ; epiretinal membranes ; fibronectin ; vimentin ; macrophages
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Proliferative vitreoretinopathy is characterized by cellular proliferations in the periretinal space resulting in traction retinal detachment. Numerous cellular elements and connective tissue components have been identified by morphologic criteria as well as immunochemical techniques. In this study, we used the recently introduced APAAP (alkaline phosphatase - anti-alkaline phosphatase) immunostaining procedure to identify macrophages, T-lymphocytes, the structural proteins fibronectin, vimentin, and cytokeratin, and a proliferating cell antigen, in eleven human epiretinal membranes obtained during vitreoretinal surgery. Our results confirm that the pathologic processes in PVR are not immunologically mediated, but reveal the features of physiologic wound healing and scar formation. Posttraumatic PVR seems to be characterized by a severe initial inflammatory reaction as evidenced by the presence of numerous macrophages, whereas idiopathic PVR, as a complication of retinal detachment, may be caused by different mechanisms in the early pathogenesis.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798296654058618882 |
|---|---|
| autor | Weller, Michael Heimann, Klaus Wiedemann, Peter |
| autorsonst | Weller, Michael Heimann, Klaus Wiedemann, Peter |
| book_url | http://dx.doi.org/10.1007/BF00130621 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM194440788 |
| issn | 1573-2630 |
| journal_name | International ophthalmology |
| materialart | 1 |
| notes | Abstract Proliferative vitreoretinopathy is characterized by cellular proliferations in the periretinal space resulting in traction retinal detachment. Numerous cellular elements and connective tissue components have been identified by morphologic criteria as well as immunochemical techniques. In this study, we used the recently introduced APAAP (alkaline phosphatase - anti-alkaline phosphatase) immunostaining procedure to identify macrophages, T-lymphocytes, the structural proteins fibronectin, vimentin, and cytokeratin, and a proliferating cell antigen, in eleven human epiretinal membranes obtained during vitreoretinal surgery. Our results confirm that the pathologic processes in PVR are not immunologically mediated, but reveal the features of physiologic wound healing and scar formation. Posttraumatic PVR seems to be characterized by a severe initial inflammatory reaction as evidenced by the presence of numerous macrophages, whereas idiopathic PVR, as a complication of retinal detachment, may be caused by different mechanisms in the early pathogenesis. |
| package_name | Springer |
| publikationsjahr_anzeige | 1988 |
| publikationsjahr_facette | 1988 |
| publikationsjahr_intervall | 8014:1985-1989 |
| publikationsjahr_sort | 1988 |
| publisher | Springer |
| reference | 11 (1988), S. 181-186 |
| schlagwort | proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages |
| search_space | articles |
| shingle_author_1 | Weller, Michael Heimann, Klaus Wiedemann, Peter |
| shingle_author_2 | Weller, Michael Heimann, Klaus Wiedemann, Peter |
| shingle_author_3 | Weller, Michael Heimann, Klaus Wiedemann, Peter |
| shingle_author_4 | Weller, Michael Heimann, Klaus Wiedemann, Peter |
| shingle_catch_all_1 | Weller, Michael Heimann, Klaus Wiedemann, Peter Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages Abstract Proliferative vitreoretinopathy is characterized by cellular proliferations in the periretinal space resulting in traction retinal detachment. Numerous cellular elements and connective tissue components have been identified by morphologic criteria as well as immunochemical techniques. In this study, we used the recently introduced APAAP (alkaline phosphatase - anti-alkaline phosphatase) immunostaining procedure to identify macrophages, T-lymphocytes, the structural proteins fibronectin, vimentin, and cytokeratin, and a proliferating cell antigen, in eleven human epiretinal membranes obtained during vitreoretinal surgery. Our results confirm that the pathologic processes in PVR are not immunologically mediated, but reveal the features of physiologic wound healing and scar formation. Posttraumatic PVR seems to be characterized by a severe initial inflammatory reaction as evidenced by the presence of numerous macrophages, whereas idiopathic PVR, as a complication of retinal detachment, may be caused by different mechanisms in the early pathogenesis. 1573-2630 15732630 Springer |
| shingle_catch_all_2 | Weller, Michael Heimann, Klaus Wiedemann, Peter Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages Abstract Proliferative vitreoretinopathy is characterized by cellular proliferations in the periretinal space resulting in traction retinal detachment. Numerous cellular elements and connective tissue components have been identified by morphologic criteria as well as immunochemical techniques. In this study, we used the recently introduced APAAP (alkaline phosphatase - anti-alkaline phosphatase) immunostaining procedure to identify macrophages, T-lymphocytes, the structural proteins fibronectin, vimentin, and cytokeratin, and a proliferating cell antigen, in eleven human epiretinal membranes obtained during vitreoretinal surgery. Our results confirm that the pathologic processes in PVR are not immunologically mediated, but reveal the features of physiologic wound healing and scar formation. Posttraumatic PVR seems to be characterized by a severe initial inflammatory reaction as evidenced by the presence of numerous macrophages, whereas idiopathic PVR, as a complication of retinal detachment, may be caused by different mechanisms in the early pathogenesis. 1573-2630 15732630 Springer |
| shingle_catch_all_3 | Weller, Michael Heimann, Klaus Wiedemann, Peter Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages Abstract Proliferative vitreoretinopathy is characterized by cellular proliferations in the periretinal space resulting in traction retinal detachment. Numerous cellular elements and connective tissue components have been identified by morphologic criteria as well as immunochemical techniques. In this study, we used the recently introduced APAAP (alkaline phosphatase - anti-alkaline phosphatase) immunostaining procedure to identify macrophages, T-lymphocytes, the structural proteins fibronectin, vimentin, and cytokeratin, and a proliferating cell antigen, in eleven human epiretinal membranes obtained during vitreoretinal surgery. Our results confirm that the pathologic processes in PVR are not immunologically mediated, but reveal the features of physiologic wound healing and scar formation. Posttraumatic PVR seems to be characterized by a severe initial inflammatory reaction as evidenced by the presence of numerous macrophages, whereas idiopathic PVR, as a complication of retinal detachment, may be caused by different mechanisms in the early pathogenesis. 1573-2630 15732630 Springer |
| shingle_catch_all_4 | Weller, Michael Heimann, Klaus Wiedemann, Peter Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages proliferative vitreoretinopathy epiretinal membranes fibronectin vimentin macrophages Abstract Proliferative vitreoretinopathy is characterized by cellular proliferations in the periretinal space resulting in traction retinal detachment. Numerous cellular elements and connective tissue components have been identified by morphologic criteria as well as immunochemical techniques. In this study, we used the recently introduced APAAP (alkaline phosphatase - anti-alkaline phosphatase) immunostaining procedure to identify macrophages, T-lymphocytes, the structural proteins fibronectin, vimentin, and cytokeratin, and a proliferating cell antigen, in eleven human epiretinal membranes obtained during vitreoretinal surgery. Our results confirm that the pathologic processes in PVR are not immunologically mediated, but reveal the features of physiologic wound healing and scar formation. Posttraumatic PVR seems to be characterized by a severe initial inflammatory reaction as evidenced by the presence of numerous macrophages, whereas idiopathic PVR, as a complication of retinal detachment, may be caused by different mechanisms in the early pathogenesis. 1573-2630 15732630 Springer |
| shingle_title_1 | Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy |
| shingle_title_2 | Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy |
| shingle_title_3 | Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy |
| shingle_title_4 | Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:55:31.733Z |
| titel | Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy |
| titel_suche | Immunochemical studies of epiretinal membranes using APAAP complexes: Evidence for macrophage involvement in traumatic proliferative vitreoretinopathy |
| topic | WW-YZ |
| uid | nat_lic_papers_NLM194440788 |