Synthesis of 1,3-thiazoline derivatives from β-dicarbonyl compounds and phenacyl thiocyanate
| ISSN: |
1573-9171
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| Keywords: |
phenacyl thiocyanate ; β-dicarbonyl compounds ; keteneN, S-acetals ; nickel acetylacetonate ; 1,3-thiazoline derivatives ; boron chelates
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
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| Notes: |
Abstract Acetylacetone and ethyl acetoacetate undergo addition at the C≡N bond of phenacyl thiocyanate in the presence of Ni(acac)2 to give the respective keteneN, S-acetals, which undergo smooth cyclization to afford 2-methylene-4-phenyl-1, 3-thiazoline derivatives when refluxed in THF.
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| Type of Medium: |
Electronic Resource
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| URL: |