Synthesis of 5-azaadenine derivatives from N-(1,2,4-triazol-5-yl)amidines
| ISSN: |
1573-9171
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
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| Notes: |
Abstract A method is proposed for the synthesis of N-substituted 5-azaadenines. The condensation of N-(1,2,4-triazol-5-yl)amidines with trichloroacetonitrile gives trichloromethyl derivatives of 1,2,4-triazolo[1,5-a]-1,3,5-triazines, which are converted by the action of primary or secondary amines into N-alkylamino- or N,N-dialkylamino-1,2,4-triazolo-[1,5-a]-1,3,5-triazines (5-azaadenines).
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| Type of Medium: |
Electronic Resource
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| URL: |