Synthesis of 2,4-diamino-5-acetyl(ethoxycarbonyl)pyrimidines from β-dicarbonyl compounds and dicyandiamide and their use for building a pyrimido[4,5-d]pyrimidine system
| ISSN: |
1573-9171
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Chemistry and Pharmacology
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| Notes: |
Abstract 2,4-Diamino-5-acetyl(ethoxycarbonyl)-6-methyl(phenyl)pyrimidines were obtained by the reaction of acetylacetone and β-ketocarboxylic acid esters with dicyandiamide in the presence of Ni(OAc)2. It was shown that annelation of the pyrimidine ring with this compound provides a convenient method for building the pyrimido[4,5-d]-pyrimidine system. New derivatives of 2-aminopyrimido[4,5-d]pyrimidine, 7-amino-3H-pyrimido[4,5-d]-pyrimidin-4-one, and 7-amino-1H,3H-pyrimido[4,5-d]-pyrimidine-2,4-dione were synthesized.
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| Type of Medium: |
Electronic Resource
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| URL: |