BAG-1 inhibits p53-induced but not apoptin-induced apoptosis
Danen-van Oorschot, A. A. A. M. ; den Hollander, A. I. ; Takayama, S. ; Reed, J. C. ; van der Eb, A. J. ; Noteborn, M. H. M.
Springer
Published 1997
Springer
Published 1997
| ISSN: |
1573-675X
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|---|---|
| Keywords: |
Apoptosis ; apoptin ; BAG-1 ; Bcl-2 ; p53 ; programmed cell death
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract BAG-1 has been identified as a Bcl-2-binding protein that inhibits apoptosis, either alone or in co-operation with Bcl-2. Here we show that BAG-1 inhibits p53- induced apoptosis in the human tumour cell line Saos-2. In contrast, BAG-1 was unable to inhibit the p53-independent pathway induced by apoptin, an apoptosis-inducing protein derived from chicken anaemia virus. Whereas BAG-1 seemed to co-operate with Bcl-2 to repress p53-induced apoptosis, co-expression of these proteins had no inhibitory effect on apoptin-induced apoptosis. Moreover, Bcl-2, and to some extent also BAG-1, paradoxically enhanced the apoptotic activity of apoptin. These results demonstrate that p53 and apoptin induce apoptosis through independent pathways, which are differentially regulated by BAG-1 and Bcl-2.
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| Type of Medium: |
Electronic Resource
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| URL: |