Life without myoglobin
| ISSN: |
1420-9071
|
|---|---|
| Keywords: |
Key words. Myoglobin; oxygen transport; heart; skeletal muscle; transgenic mice.
|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Biology
Medicine
|
| Notes: |
Abstract. Hemoproteins are widely distributed among prokaryotes, unicellular eukaryotes, plants and animals . Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria . This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists . Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin . This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle.
|
| Type of Medium: |
Electronic Resource
|
| URL: |