Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome
| ISSN: |
1420-9071
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| Keywords: |
Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease.
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Biology
Medicine
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| Notes: |
Abstract. Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798295349043920896 |
|---|---|
| autor | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. |
| autorsonst | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. |
| book_url | http://dx.doi.org/10.1007/PL00000661 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM18940714X |
| iqvoc_descriptor_keyword | iqvoc_00000124:transport |
| issn | 1420-9071 |
| journal_name | Cellular and molecular life sciences |
| materialart | 1 |
| notes | Abstract. Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD. |
| package_name | Springer |
| publikationsjahr_anzeige | 2000 |
| publikationsjahr_facette | 2000 |
| publikationsjahr_intervall | 7999:2000-2004 |
| publikationsjahr_sort | 2000 |
| publisher | Springer |
| reference | 57 (2000), S. 1810-1816 |
| schlagwort | Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. |
| search_space | articles |
| shingle_author_1 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. |
| shingle_author_2 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. |
| shingle_author_3 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. |
| shingle_author_4 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. |
| shingle_catch_all_1 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Abstract. Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD. 1420-9071 14209071 Springer |
| shingle_catch_all_2 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Abstract. Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD. 1420-9071 14209071 Springer |
| shingle_catch_all_3 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Abstract. Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD. 1420-9071 14209071 Springer |
| shingle_catch_all_4 | Kim, S. H. Vlkolinsky, R. Cairns, N. Lubec*, G. Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Key words. Ubiquinol:cytochrome c oxidoreductase; ATP synthase; mitochondrial electron transport chain; Alzheimer’s disease; Down syndrome; neuronal cell death; neurodegenerative disease. Abstract. Ubiquinol:cytochrome c oxidoreductase (complex III) and ATP synthase (complex V) are important enzymes in the mitochondrial electron transport chain. Defects in mitochondrial respiratory enzymes have been reported for several neurodegenerative diseases. In this study, we applied the proteomic approach to investigate protein levels of complex III core protein 1 and complex V β chain in brain regions of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Complex III core protein 1 was significantly reduced in the temporal cortex of AD patients. Complex V β chain was significantly reduced in the frontal cortex of DS patients. We conclude that decreased mitochondrial respiratory enzymes could contribute to the impairment of energy metabolism observed in DS. These decreases could also cause the generation of reactive oxygen species and neuronal cell death (apoptosis) in DS as well as AD. 1420-9071 14209071 Springer |
| shingle_title_1 | Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome |
| shingle_title_2 | Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome |
| shingle_title_3 | Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome |
| shingle_title_4 | Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome |
| sigel_instance_filter | dkfz geomar wilbert ipn albert fhp |
| source_archive | Springer Online Journal Archives 1860-2000 |
| timestamp | 2024-05-06T09:34:47.398Z |
| titel | Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome |
| titel_suche | Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer’s disease and Down syndrome |
| topic | W WW-YZ |
| uid | nat_lic_papers_NLM18940714X |