Changes in the activities of protein kinase modulators in the cerebellum of mice due to ethanol, caffeine, or phenobarbital administration
Kuo, W. N. ; Williams, J. L. ; Floyd-Jones, T. ; Duggans, C. F. ; Boone, D. L. ; Smith, S. O. ; Copeland, R. F.
Springer
Published 1979
Springer
Published 1979
| ISSN: |
1420-9071
|
|---|---|
| Source: |
Springer Online Journal Archives 1860-2000
|
| Topics: |
Biology
Medicine
|
| Notes: |
Summary Decreased activities of both the inhibitory modulator of adenosine 3′∶5′-monophosphate (cAMP)-dependent protein kinase (A-PK) as well as the stimulatory modulator of guanosine 3′∶5′-monophosphate (cGMP)-dependent protein kinase (G-PK) from the mouse cerebellum were noted due to the administration of excessive doses of ethanol, caffeine, and phenobarbital for up to 28 days. The dose-dependence of the inhibition of A-PK or the stimulation of G-PK was observed as a function of the amount of protein kinase modulators in the cerebellum of mice receiving different doses of ethanol.
|
| Type of Medium: |
Electronic Resource
|
| URL: |