Inhibition of neutrophil adherence to endothelial cells by 3-deazaadenosine
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1420-908X
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract Treatment of cultured human umbilical vein endothelial cells (HUVE) with tumor necrosis factor alpha (TNF-α) increases their capacity to adhere human neutrophils. We have found that 3-deazaadenosine (c3Ado), when added in conjunction with TNF-α, inhibited this increase in neutrophil adherence. This activity of c3Ado was potentiated by the addition ofl-homocysteine thiolactone (Hcy). The ability of c3Ado to inhibit neutrophil adherence to HUVE may contribute to the anti-inflammatory activity of this nucleoside analogue.
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| Type of Medium: |
Electronic Resource
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| URL: |