Involvement of leukotrienes and PAF-acether in the increased microvascular permeability of the rabbit retina
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1420-908X
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| Source: |
Springer Online Journal Archives 1860-2000
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| Topics: |
Medicine
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| Notes: |
Abstract The effects of intravenous injection of PAF-acether and of leukotrienes LTB4 and LTD4 on rabbit retina were determinedin vivo in the unanaesthetized animal. PAF-acether induced an intense ischemia accompanied by a marked plasma leakage. The extravasation remained both in the platelet-depleted rabbit where a sludge phenomenon appeared and in the reserpine-treated animal. Prostacyclin injected after PAF-acether restored only partially the normal retinal appearance. The effect of LTC4 and LTD4 was markedly less intense than PAF-acether which is not too surprising in this species, given the previous results.
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| Type of Medium: |
Electronic Resource
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| URL: |